This paper presents a literature review related to ju-venile osteoporosis. Researching into both mechanism of patho-genesis of this disease and metabolic disorders in childhood and adolescence is essential to take therapeutic measures betimes. Long-term medical treatment that is required until the peak os-seous mass values correspond to regular ones will make for better quality of patients' life and decrease of fracture risk. In general, this will have considerable social and economic effect.

Etiology and pathogenesis of nosocomial pneumo-nia are observed. New principles of starting empirical antibiotic therapy are presented. Advantages of meropenem starting phar-macotherapy of nosocomial pneumonia are discussed and sub-stantiated in our article.

Sleep respiratory disorders should be timely diagnosed being of essential clinical significance. Polysomnography is aimed at synchronized monitoring to define the type of apnea, duration and stages of slumber, episodes of awakeness within the sleep pe-riod, snoring frequencies. All these aforementioned indices might be helpful to outline protocols of therapy or surgical management.

Based on 37 observations the authors have studied the level of local cytokines in supernatants of liver biopsies under the conditions of chronic viral hepatitis and showed correlations between the levels of different cytokines and the degree of inflam-matory manifestation and sclerosis. They came to a conclusion about cytokine-mediated mechanisms of necrotic inflammatory and fibroplastic processes in liver under chronic viral hepatitis.

68 patients suffering from insular diabetes and 88 pa-tients having insular diabetes in combination with stomach ulcer underwent daily pH metering of oesophagus and esophagoscopy to diagnose gastroesophageal reflux disease. In the course of examination gastroesophageal reflux disease was confirmed for 18,8% of patients suffering from type I diabetes and 19,4% of pa-tients with type II diabetes. The author has ascertained that the patients suffering from insular diabetes associated with stomach ulcer had had gastroesophageal reflux disease more often. If the patients had insular dependent diabetes of type II associated with stomach ulcer, then gastroesophageal reflux disease was, mostly, diagnosed and in a half of disease cases was characterized by as-ymptomatic disease course.

NO-synthetase localisation and activity was ex-amined by method of V. Hope, S. Vincent on NADPH-diaph-orase (NADPH-d, coenzyme factor). It is possible to identify three types NADPH-d-positive cells with high, medium and low activity of enzyme during research of oblong brain cuts painted on NADPH-d. Enzyme's activity in pelvic presenta-tion of the fetus to decrease to 9%, in comparison with cranial presentation. NO-inhibitors causes constriction of brain ves-sels, and in some cases their administration is accompanied by basal blood circulations decrease in these organs, including in antenatal period of ontogenesis with consequences following from here.

The authors have conducted light-optical and electron microscopical studies of 21 eyes of human foetuses (therapeutic abortions in the first, second and third trimesters of pregnancy) and shown that changes in the form, increase in body size and proliferation of dendrites of neurons of ganglionic layer correlated with intrauterine growth. By the time of birth, M-neurons of retina were mature from the point of view of their morphologic structure.

Experimental researches conducted by using vid-eography, computed tomography, magnetic resonance imaging procedure, histological and histochemical methods showed that white rat's supramaxillary sinus is a full-fledged anatomic mass. Its mucous membrane by its structure can be compared with the structure of mucous membrane of human maxillary sinus and is fit for pathologic processes simulation.

Objective of study was to study relation of VDR and COL1A1 gene's polymorphism in adolescences with carriage dis-orders. We investigated 45 adolescences with carriage disorders. Condition of bone metabolism was estimated on blood osteocal-cini (OC) and вCrossLaps (вCL) concentration by immunoas-say method. BsmI polymorphism of length of restrictive fraction VDR3 (genotypes BB, Bb, bb) and Sp1 polymorphism COL1A1 (genotypes SS, Ss, ss) was studied using PCR. Control group was consisted by 40 health adolescences similar ages and a sex. We discovered significant different between average indices of OC level in adolescences with carriage disorders with genotypes BB, Bb and bb (BsmI-polymorphism). The difference between CL levels is found only for SS and ss genotypes. Conclusion: a poly-morphism VDR3 and COL1A1 gene has intimately relation with bone metabolism markers in adolescences with carriage disor-ders and it is key genes in development of osteopenic syndrome.

Bilateral bronchophonography helped to detect acoustic focus at 75% of patients suffering from pneumonia (sensitivity - 0,75, specificity - 0,86) that confirms comparability between this method and traditional procedures (examination, palpation, percussion, auscultation). Main advantage of this method consists in a possibility to describe inflammatory focus objectively (qualitatively and quantitatively) during examination and in dynamics, and to create individual archives of acoustic data. Besides, bilateral bronchophonography is non-invasive, non-ionizing and safety procedure that, if required, allows to perform frequent monitoring of the pathologic focus in the lung detected by using X-ray examination, including in cases when capabilities of X-ray examination are limited (for example, preg-nant women, nursing mothers).

The purpose of this paper is to make examination of pregnant women in both Khabarovsk and Vladivostok for uro-genital infections pathogens. A special attention is focused on those microorganisms, as to which there is no settled opinion re-garding diagnostics, features of clinical presentations, therapeu-tic and preventive approaches. The authors estimate frequency of infection among different categories of pregnant women and trace the level of born children's health, ascertain bacterial resis-tance to the therapy used, and offer schemes of integrated medi-cal treatment of the most frequent urogenital infections.

Heart rhythm and conduction disorders were studied in 57 patients both male and female at the age of 16 to 60 years with false tendons in left ventricle and innate or acquired mitral valve prolapse. All patients underwented fisical examinations, thorough echocardiographic evoluation, ECG, diagnostic scope of blood pressure and Holter ECG monitoring. The subject of false tendons and heart rythm disorder connections is being dis-cussed. In case of the false tendons in the left ventricle the grave heart ryhthm and conductions disorders can be also found, espe-cially if a pation already has mitral valve prolapse. The location of false tendons at angle 45° towards transfering tract of the left ventricle case to obstruction and required to make a differential diagnosis with heard malformation.

The mathematical approach to formation of clini-cal groups, modeling of types of the clinico-functional condi-tion of patients by a heart attack of a myocardium is used. As a result of the classification it is received 4 klasters, consisting of homogeneous objects. The differentiated complexes of regen-erative therapy are developed on the basis of aerobic physical rehabilitation and individual purpose natural and preformed therapeutic factors by a sick heart attack of a myocardium.

Based on clinical anamnestic and instrumental data and 200 medical observations of autoimmune thyroiditis the authors have distinguished 3 groups of patients. Conservative therapeutic approach included application of a wide number of physiotherapeutic procedures in combination with drug treat-ment. Differentiated approach allowed substantially improving the results of conservative treatment and thyroid gland structure, decreasing the scope of autoimmune aggression and manifesta-tions of hypothyroidism.

The authors have examined 140 patients suffering from irritated bowels syndrome. 72 patients underwent anal ma-nometry in hospital and 51 patients received monthly course of medical treatment by using dicetel. At 30,6% of cases the au-thors diagnosed irritated bowels syndrome associated with anal sphincters dysfunction. Upon treatment manifestations of the irritated bowels syndrome abated, this notwithstanding the anal sphincters dysfunction remained and declared itself clinically as cases of refractory constipation.

Based on the results of medical examination of 226 men who had taken diuretics for a long time, the authors de-tected pharmacoiatrogenic sexual disorders at 15,9% of patients. The highest risk occurred when the patients took furosemide, ac-etazolamide and hydrochlorothiazide. Among the safest medi-cations were indapamide and triamterene. The patients with pharmacoiatrogenies suffered from poor sexual constitution and somatic psychogenic disorders.

Effect of drugs on men's sexual function is of great importance in forensic medical practice in view of the fact that there are medical products that may both inhibit copulative cycle and stimulate it. The authors have studied effect of drugs produced on sexual function taking into account 400 anony-mous questionnaires and ascertained that chronic diseases and drugs applied to treat them, as well as long-lasting stress situa-tions have negative effect on erectile function. Some men occa-sionally or on continuing basis take drugs that enhance sexual function, including without consulting with the doctor. This fact and an opportunity to take drugs inhibiting sexual function prior to forensic medical examination of suspects in rape make difficulties for forensic medical examination of men's sexual functions.

The authors have analysed 477 clinical observations of stomach and duodenal ulcer and chronic gastritis associated with Helicobacter pylori and showed that the reliability of labo-ratory diagnostics increases, if several diagnostic procedures are used. Upon combined therapy effectiveness of eradication amounted to 71-74%.

Definition of the contents of microcells-antioxi-dants cuprum and zinc in plasma of blood and in hair of preg-nant women of group of risk on miscarriage pregnancy is car-ried out (spent). It is revealed, that the increase of the contents cuprum in plasma of blood at women is marked, pregnancy at which proceeded with clinical displays miscarriage pregnancy in comparison with women with physiological current of preg-nancy. At comparison of the contents of zinc in plasma of blood with physiologically proceeding pregnancy and at women, preg-nancy at which has become complicated miscarriage authentic decrease of concentration of zinc is revealed. Inclusion of the given researches in the program of inspection of women of group of risk on miscarriage pregnancy will allow to consider the given changes as a risk factor of development miscarriage and in due time to carry out medicamentous correction.

The authors have carried out researches into clinical application of amplodipin (novarska) in outpatient department during 14 weeks. They were examining 36 patients of mean age suffering from essential hypertension and came to a conclusion that this medical product was efficient enough and easy-to-use.

108 patients have been examined for ixodic tick bor-reliosis (clinical and epidemiological parameters). It is shown that this pathology is of current importance for the Region in-habitants. Erythemateous and in-erythemateous forms of this disease are registered there. General intoxication syndrome is more evident at patients suffering from in-erythemateous form. Furthermore, there is a cellular immunity hyperactivation. Im-mune response type is dependent on the form of the disease: Th2-type prevails under erythemateous form in acute period; mixed Th1/Th2-type prevails under in-erythemateous form.

The prevailing virus C hepatitis genotype in Primor-sky Region is 1b (43%), then follow in descending order and mixed variants (among which the most important is the combination of 1b and Intravenous introduction of drugs (and mechanism of infection, thereafter) predominates among the infection risk factors.

The authors provide the results of the pilot morpho-logic and statistical researches in relationship between brain de-velopment parameters in foetuses and state of ovaries and adrenal cortex of their mothers. They set up a hypothesis according to which low reproductive performance and lesser adrenal cortex ac-tivity, as compared with the "average statistical one", in mother's organism provoke precocious brain development in progeny.

The authors describe original procedures for deter-mining dosage of chemical drugs (half-effect doses, optimum and maximum permissible doses) in the course of experiments on correction of effects produced upon organism by physical factors. This method has been approved in experiments run to correct effects of electromagnetic radiation on fertilization pro-cesses in sea-urchins and can be applied in the course of various experimental researches into dose-response relationship.

It is shown, that low a parameter the index of ac-tivity cytokine regulation allows to reveal authentically in early terms allergic diseases on not clinical a stage of development of disease. The index of activity cytokine regulation allows to de-fine ability of cells to produce cytokines as one of parameters of the immune answer which represents unconditional value for the characteristic of the immune status as one of criteria of revealed biological defects at early stages of disease.

Intraoperating support of ventilation is carried out in various modes - at the kept independent breath, with the help of artificial ventilation easy (IPPV) and various variants of aux-iliary ventilation. The basic method of carrying out of ventila-tion is compulsory volumetric ventilation with positive pressure with a high, small and low stream gas mixes. There are rather useful methods of high-frequency ventilation at carrying out of complex lungs operations. Modern requirements to safety of an-esthesia and adequate ventilating support demand constant in-formative monitoring.

The paper describes a procedure of modern math-ematic image analysis based on the computer morphometry and discriminatory analysis. The authors have focused a special at-tention on researching into activity of ribosomes' nucleolar or-ganizer under the conditions of light and electron microscopy that allows differentiating malignant and benign tumors form-ing in many organs and prognosing the course of the pathologic process.

Adhesive activity of peritoneal macrophages and state of their lysosomal membranes stability by their attachment to plastics and glass were determined by original methods. It was shown that peritoneal macrophages' ability to attach to plastics is higher than to glass. This way, rise of ILMS occurs in case of their attachment to plastics during different time period of in-teraction between peritoneal macrophages and glass or plastics, that is associated with rise of phagocytes' lisosomal membranes labilization.

The paper presents brief literature review related to the role of eicosanoids under chronic inflammatory dermatoses. The author highlights a necessity of modern approaches to treat-ment of chronic inflammation and application of polyunsaturat-ed fatty acids that block generating arachidonic acid, a precursor of eicosanoids in human organism.

The paper represents an observation from the medi-cal practice. In the course of post-mortem examination the au-thors found massive lung melanoma associated with superficial brachial melanoma in an oncologic patient who had died of multiple metastases, including metastases in brain. Based on the gross impression, the features of metastatic disease and histologi-cal studies they came to a conclusion about initial involvement of the lung. Superficial brachial melanoma was at pre-metastatic growth stage and characterized by other cytological parameters.

The authors have analysed the features of oncologic morbidity among the Primorsky Region population. Ecologic and medical assessment of the regional environment and the habitat showed that among the major factors of oncologic risk is a man-made environmental pollution. Notwithstanding the shrinkage in capacity that has been a very representative feature of the last ten years and the decrease in number of industrial dis-charges, environmental pollution level remains high for a num-ber of territories, as before.

Epilepsy is a medical and social issue of the day. To-day throughout the world the sickness rate is 50 - 70 persons per 100000 inhabitants, while its prevalence is 5-10%. Epilepsy does great damage to the economy (expenditures for treatment, medi-cal rehabilitation and losses in industry). The situation can be only changed by means of creating the system of adequate care and disease-prevention service based on exact epidemiological investigations. The paper provides a literature review and au-thors' data.

The paper provides a review related to researches conducted at the chair of infectious diseases in Vladivostok State Medical University and describes the contribution made by the chair's personnel to researching into Far-Eastern scarlet-fever-like fever, hemorrhagic fever associated with renal syndrome, trichinosis, malaria, measles, tick-borne encephalitis, tick-borne ricketsiosis, and other infections and invasions.