The author presents an article dedicated to the forty-fifth anniversary of Vladivostok State Medical University where he surveys its activities and prospects for the future. Moreover, the scientist cites data about the teaching, methodical, scientific and medical work of the University, then marks the positive tendencies towards specialists' and scientists' training, the international cooperation expansion. Furthermore, the priority directions for the system of open-ended higher education are formulated by the author, and the dynamics and trends of the renewal of the material and technical basis of the institution, the updating of publications and the quality of methodical equipment of the educational process are shown as well. The scientist places high emphasis on the social sphere and prophylactic direction of the university work and bounds up the prospects for the further development of Vladivostok State Medical University with more outright realization of the principle of the economy and management priority over the politics.

The survey presents the analysis of segmental and su-praspinal nitroxidergical mechanisms of pain sensitivity regulation. In systemic integrative pain reaction the nitric oxide is a participant of all its components being connecting-link between afferent painful impulsation and adaptative change of central nervous system. In the nitric oxide synthesis system the painful impact is accompanied by considerable changes, their intensity and directedness have specific profile in different brain structures and depend on pain parameters. Enhancing the tonus of upward nociceptive systems, the nitric oxide at the same time controls endogenous antialgesic mechanisms and can have an influence upon the effectiveness of analgesic effect of opiates. Thereupon nitroxidergical brain system can be regarded as potential target for complex drug pain therapy.

The authors present the basic data about joint scientific achievements of the Scientific Research Institute of Epidemiology and Microbiology of Siberian Branch of Russian Academy of Medical Sciences and Vladivostok State Medical University in the domain of study of the infectious diseases widespread in Primorsky region as for instance tick-borne encephalitis, hemorrhagic fever with renal syndrome, pseudotuberculo-sis, salmonellosis. They adduce the results of the united researches with respect to food tinrostim supplement use during medical treatment of patients with different diseases combined with immune abnormalities as well. The specialists characterize scien-tific-and-organizational, teaching and educational contacts of the stated institutions.

The authors present the survey of the literature dedicated to the women' urination disorders and show that thus far there is no unified well-grounded for women treatment-and-diagnostic algorithm which could be analogous to that exists for men with benign prostatic hypertrophy. In view of a great range of urodynamics disorders, by no means all the methods turn out to be effective, and furthermore, the therapeutic measures, disregarding the impact on leading or important pathogenetic link, are of little success. To apply the up-to-date medications of transmitter and vascular therapy is more effective, when a doctor has a good chance to estimate evenly the clinic picture and make necessary changes of the treatment regimen. It will allow early and for certain to diagnose and treat patients, soundly fulfill conservative therapy or surgical operation.

During the recent years, a high emphasis is placed on the computed electrocardiotopography. Notwithstanding the advantages of the method over the standard ECG, the mapping of the surface of body has not become a widespread method because of the complexity to interpret the findings. A group of 74 practically healthy persons (59 men and 15 women) has been examined. The complex analysis of the heart electric field, according to computed electrocardiotopograph data, has enabled to study and describe adequately the features of the electrocar-diotopograms of the healthy patients with normal, horizontal and vertical position of electrical axis of heart.

These researchers showed the analysis of 1821 medical histories of the patients of specialized infarction department so as to assess the clinical course of the disease. They examined 50 patients, both men and women, at the age of 37-79 years with acute coronary syndrome, and 62 patients at the age of 25-50; 45 persons suffered from different forms of ischémie heart disease; among them there were 17 patients with risk factors for ischémie heart disease development. The examination included the detection of NO metabolite content, the tumor necrosis factor and C-reactive protein and sex hormones in blood serum. The young patients had the infarct that developed suddenly and proceeded with anxious and phobic reaction whereas the patients in years had depressive disorders. It was shown the reliable change of the sex hormones level of the men and women aged till 50 with risk factors and of patients with ischémie heart disease. The NO-producing system of vessel endotheli-um was reducing especially as regards the persons of the elderly age. The examined immune activation markers were bound up with coronary syndrome form and with the patients' age.

The analysis of the physical growth and development of children and teenagers of Vladivostok at the age of 3-18 for the years 1996-2002 is shown in these studies. The findings concerning the dynamics of statural-weight values, vital capacity of lungs, arterial pressure and dynamometry are the evidence of trophological insufficiency and increase of period of catabolic processes of the children and teenagers of Vladivostok during the recent decades.

The individual health level of the students was detected with the help of the activation prophylaxis methods and therapy, cardiointervalography. The authors had been finding the style of self-regulation of psychophysiologic functional state, coronary type of behavior and biological age index. It was shown up the correlation of the level of health and normal meanings of tension index and harmonious self-regulation style. A positive dynamics of adaptive state had been observed in the cases of the persons with small-scale of ageing in combination with normotonia or moderate sympathieotonia. By means of phytogenic adaptogens, prescribed in compliance with the computerized programme «Antistress», there had been carried out the correction of the patients' functional state. The extracts of Aralia Manchurian and Rodiola Roseo were more effective due to the fact that they had made for psychophysiologic amelioration of the students.

In these researches the chair of faculty therapeutics of Vladivostok State Medical University conducted a study in order to detect the students suffering from undifferentiated connective-tissue dysplasia syndrome. 68 persons at the age of 18-31 have been examined. 56 persons had the syndrome shown up in different manifestations: lesser cardiac development anomalies, articular hyper-mobility, spinal column pathology, bleeding sickness and so forth. As summarized, the indices of central hemodynamics of the persons were of normality and formed the eukinetic type of blood circulation. At 33,9 per cent of cases anomalous chordas and left ventricle trabecules were detected, at 32,1 per cent there were the evidences of mitral valve prolapse. The authors were quite often registering the dilatation of Valsava's sinus (19,6 per cent of cases), the anomalies of heart papillary muscles (26,8 per cent). During the ECG the syndrome of early ventricle repolarization was shown up at 25 per cent of students; 7,1 per cent of patients had long QT syndrome and 3,6 per cent of persons were subject to extrasystole.

An increase of strains of infections disease microbes that are resistant to antimicrobial medications has been registered for some period of time. In Russia the problem for monitoring of formation and circulation of antibiotic-resistant strains is that there is lack of standardized procedures to evaluate the antibiotic susceptibility of the microorganisms and the production control standards. To heighten the medical experts' information distribution about efficient use of antibacterial chemopreparations based on regional level findings, there has been carried out the study with respect to the susceptibility of the strains of S. pneumonia, S. pyogenes and N. gonorrhoeas received in Vladivostok.

The researchers present the results of the study with respect to the sickness rate of the streptococcal infection (scarlatina, anginas) and of rheumatism on the territory of Primorsky region since the years 1991 till 2001. A technique of non-traditional epidemiological analysis worked out by the authors on the basis of the self-regulation theory as to the parasitic systems has been also applied within the framework of the study. They have received the data about self-maintained development of the epidemic process of the strepto-coccosis on the five territories that are considered as population epidemic focuses. The rheumatism morbidity has been developing as provided by the role of the territory in the epidemic process of the streptococcosis.

The authors gave the analysis of 18 cases of pulmonary tuberculosis of the patients of elderly age. The specific process of the disease development has been accompanied by erythema no- dosum. This shows the heightened aggressiveness of the infection nowadays. Granting the fact that the patients at the age of 60 and upward quite often have some somatic diseases, the onset of the erythema nodosum gives solid grounds to make a referral to patient examination on account of pulmonary tuberculosis.

This study describes mass and sporadic episodes of anthrax on the territory of Primorsky region of Russia. The sources of people's infection and animal diseases were burial grounds of cattle remained after anthrax epidemic in 1904. It is also pointed to the necessity of being on the epidemiological alert with respect to this disease.

As compared with the total sickness rate of skin diseases, the amount of viras dermatoses of water transport workers registered during the years 1997 - 2001 averaged 24%. At the same time the number of cases increased in 3 times more, and the quantity of morbidity days increased in 1,2 times. Among the viras dermatoses, 34% of them fell on recurrent genital herpes. During the medical observation of 108 workers of marine staff, a seasonal dependence of herpetic dermatosis, and its association with the profession were ascertained. Furthermore, the information about immunity disturbance of the patients with herpes was presented there, and a complex stepwise treatment mode along with domestic preparation use was worked out and could be recommended for out-patient treatment under conditions of open-ended navigation.

These researches show a considerable increase in lysozyme secretion while the viruses were acting on peritoneal macrophages of rats. The effect is applied under carrying out of authors' method of vesicular stomatitis virus detection. The scientists note toxic action of high doses of lysozyme on peritoneal cells as well. They have studied the mechanism that determines heightened lysozyme secretion owing to instability of lysosomal macrophages' membrane within viruses' action.

The authors studied humoral immunity state of 32 patients with psoriasis. On the ground of antibodies detection to gut organisms it is recommended to lower the humoral immune response level under this disease notwithstanding the traditional therapy. The group of the scientists considers that there is a need to treat medically concomitant gastrointestinal tract diseases and normalize microbiocenosis of bowels for effective host defenses recovery.

On the ground of the analysis of literary information, 55 autopsies and 5 biopsies, the authors describe the morphology of Coxsackie infection of the adult patients. The diagnosis has been confirmed with virological study and morphologic markers. It is pointed to the tropity of the pathogen to the transversely striated musculature including the cardiac muscle. Furthermore, it is analyzed the dynamics of the acute and chronic involvement of the internals, endocrine glands and central nervous system. The authors come to a conclusion about a considerable role of Coxsackie viruses of the B-group of the adults in the internal diseases clinic, and emphasize the necessity of well-timed diagnostics of the infection where the biopsy examination can be of positive importance.

The rat testicles were examined with morphologic and biochemical methods in 1,3,6 and 12 months after adding the cod-liver oil to food mixture on the basis of 0,1 g/kg of body weight. After cod-liver oil use within 1-3 months, some degenerative changes of the spermatozoa and spermatids came to light at 8-12 per cent of convoluted seminiferous tubules. The cholesterol concentration has reduced almost by 20 per cent, and the phospholipid content of the lipid extract of testicles has increased by 16 per cent. Drug application within 6-12 months has resulted in lesion of spermato-cytes and spermatogones at 30-60 per cent of tubules, in increase of the testicle cholesterol level, in fatty degeneration of some part of gametes. Moreover, it was noted that differentiated elements of sper-matogenic epithelium of convoluted seminiferous tubules suffered to a greater extent that, possibly, had been brought about by retinol high doses coming into organism along with cod-liver oil.

The fine needle aspiration biopsy is the first step in the process of differential diagnostics of nodular lumps of the thyroid gland. The author presents the analysis of morphomet-rical parameters of thyrocytes during benign thyroid gland diseases. Based on information theory positions, the scientist gives the characteristic of morphologic system state and points out its shifts under the different pathologic conditions.

In the researches the authors have focused their attention on the examination of 30 patients with drug dependence at the time of active drug use and of 20 practically healthy persons of the same age. The indices of lipid peroxidation, antirad-ical activity, biochemical indices (enzymes, whole protein, albumin, urea, glucose, lactate, cholesterol, triglycérides) were determined in the expired air condensate. A substantial increase of lipid peroxidation volume, an antiradical activity reduction and a considerable alteration of the biochemical expired air condensate composition of the drug addicts were shown during the examination and could be considered as premorbid background for bronchopulmonary pathology development.

This study describes the results of the tests of blood Theological properties of 87 patients with chronic pros-tatitis. A considerable increase of blood viscosity most evident under parenchymatous form of the disease and in case of complications (epididymite, vesiculitis) has been detected there. The author has observed the statistically significant increase of erythrocyte aggregation index early in the development of the prostatitis. When complications, he has noted some decrease of the erythrocyte capacity for deformity. In all probability, hematocrit increase was an adaptive response during the oxygen provision disturbance. Electromagnetic radiation of millimetric range has stimulated the correction of the disorders of blood Theological properties.

The original technique of non-invasive and the methods of little invasive ness diagnostics of diffuse and focal liver diseases are set forth in the presented work. The authors discuss the principles of the endovascular surgery of liver diseases; give the examples of the basic drug regimens for in-traportal infusion; mention the matters of prophylaxis of bleedings from cannulated portal vein flows. They study the results of the use of their own surgical instruments made of hypocrystalline biomaterial.

The authors have examined 34 children aged from three months to nine years with celiac disease (16) and lac-tase deficiency (18). They have detected nitroxide-producing function of mucous membrane of small intestines. The findings are the evidence of the participation of nitroxidergic mechanisms in the intestinal absorption processes. The peak level of nitroxide synthesis has coincided with the most apparent clinical presentations of the malabsorption: as the intestinal syndrome intensity decreased, nitroxide synthase activity of enterocytes went down.

By giving the example of 349 fishermen with verte-brogenous pain syndromes when being at sea for a long time and working in difficult and extreme situations, the author grounds the possibility to apply efficiently the manual therapy. These studies considerably extend the scope of this treatment mode.

The authors present the results of the epidemiological researches concerning the postoperative purulent-and-septic infections inside the surgical departments of the Central Hospital of the Pacific Navy for the years 2000 - 2002. They notice that 90 per cent of all the infectious postoperative complications (S. aureus - 61%, S. epidermidis - 19%) has fallen to the share of gram-positive coccuses, and cite the data about preventive and antiepidemic measures in view of different forms of hospital-acquired infections.

In this article the author proves the importance of the medical rehabilitation of the armed forces personnel who suffers from the widespread noninfectious diseases in the sanatorium, and presents the resources of Okeansky Military Sanatorium as leading treatment-and-prophylactic institution of this type in the Far-Eastern Military District. He also describes natural and preformed therapeutic factors used in prophylaxis and rehabilitation, and proposes the means for the enhancement of efficiency of medical rehabilitation in the sanatorium.

Seven years have passed since Vladivostok Regional Russian-Japanese Endoscopie Training Centre was organized on the initiative of the Japanese-Russian Medical Exchange Fund. In the centre there have been created quite good educational base and three-stage system for experts' training. A clinical en-doscopy residency has been inaugurated there as well, and with it some up-to-date methods of endoscopie diagnostics and treatment have been embedded in applied public health service.

This article is dedicated to the nurse business reform in the Russian Federation. Its purpose is to improve the quality of medical aid rendering for the population by means of involving and more active use of the secondary nursing staff, as well as to heighten the nurse's social significance and status in the society. The reform is tightly bound up with the transition to the market economy and with the formation of family doctor institution. The authors present their own conception of the nurse business reform adapted for the Far-Eastern region features.

The group of the scientists studies the principles of forming of legislative acts and by-laws that regulate the public health workers' activity. As is shown, nowadays there is a juridical vacuum in this field. In Russia the main legislative provisions in the area of citizens' health have not been fixed, and the exact wording of the principal provisions of the federal statute and by-laws has not been found. The authors propose their own conception of some provisions of the law «On Social Status of Medical Workers».

The group of the scientists has focused its attention on historical and analytical studies about the activity of one of the oldest medical institutions in Primorsky region - Regional Clinical Hospital. The authors have described the organization of the first medical institutions within the time of the foundation of Vladivostok consolidated afterwards into the municipal hospital, and then changed into the regional one in 1961. They have elucidated in detail the scientific activity of the first Vladivostok doctors united into the learned society, showing the formation and the development of the main medical services. The authors have paid attention to the chiefs and leading experts of the regional hospital, to the organizers of the public health. The high emphasis have been placed on the role of the research studies and cooperation with medical institute of higher education so as to train the specialists and organize medical care for the population.