Diagnostics and monitoring of the neuronal damages at patients with isolated severe brain trauma
Abstract
With the purpose of search of an accessible, reliable and simple method of an estimation of severity of brain trauma the complex exam of 17 patients in the age of 18-55 years with the analysis of the level of neuron specific protein S-100 in blood is done. It is shown, that concentration of this marker of cellular damage considerably rises in the acute period of brain trauma. At favorable current of pathological process level S-100 was considerably reduced already on 2nd day of illness. At negative changes the concentration of S-100 remained practically constant or even raised, that testified about secondary reperfusion brain damages.
About the Authors
М. Молдованов
Городская клиническая больница № 2
Russian Federation
Russian Federation
В. Тарасенко
Владивостокский государственный медицинский университет
Russian Federation
Russian Federation
А. Полещук
Владивостокский государственный медицинский университет
Russian Federation
Russian Federation
M. A. Moldovanov
Russian Federation
V. E. Tarasenko
Russian Federation
A. V. Poleshchuk
Russian Federation
References
1. Педаченко Е.Т., Лисяный Н.И., Тухтаев Н.Х. // Вопросы нейрохирургии им. Н.Н. Бурденко. - 1993. - № 1. - С. 19-21.
2. Потапов А.А., Крылов В.В., Лихтермани Л.Б. и др. // Вопросы нейрохирургии им. Н.Н. Бурденко. - 2006. - № 1. - С. 3-7.
3. Старченко А.А. Клиническая нейрореаниматология : рук-во для врачей. - М.: МЕДпресс-информ, 2004.
4. Andrew Maas I.R., Dearden M., Servadei F. et al. // Curr. Opin. Crit. Care. - 2000. - No. 6. - P. 281-292.
5. Biberthaler P., Linsenmeier U., Pfeifer K.J. et al. // Shock. - 2006. - Vol. 25, No. 5. - P. 446-453.
6. Biberthaler P., Mussack T., Kanz K.G.. et al. // Unfallchirurg. - 2004. - Vol. 107, No. 3. - P. 197-202.
7. Donate R. // Int. J. Biochem. Cell Biol. - 2001. - Vol. 33. - P. 637-668.
8. Donate R. // Microscopy Research and Technique. - 2003. - Vol. 60, No. 6. - P. 540-551.
9. Gonzalez-Martinez T., Perez-Pinera P., Diaz-Esnal B. et al. // Microscopy Research and Technique. - 2003. - Vol. 60, No. 5. - P. 633-638.
10. Ingebrigtsen T., Romner B. // Restorative Neurology and Neuroscience. - 2003. - Vol.21, No. 3-4. - P. 171-176.
11. Moore B.W. // Biochem. Biophys. Res. Com. - 1965. - Vol. 19, No. 6. - P. 739-744.
12. Pelinka L.E., Kroepfl A., Leixnering M. et al. // Journal of Neurotrauma. - 2004. - Vol. 21, No. 11. - Р. 1553-1561.
13. Raabe A., Kopetsch O., Gror U. et al. // Clin. Chem. Lab. Med. - 2003. - Vol. 41, No. 5. - P. 700-703.
14. Taheri P.A., Karamanoukian H., Gibbons K. et al. // Arch. of Surgery. - 1993. - Vol. 128, No. 3. - Р. 289-292.
Review
For citations:
, , , Moldovanov M.A., Tarasenko V.E., Poleshchuk A.V. Diagnostics and monitoring of the neuronal damages at patients with isolated severe brain trauma. Pacific Medical Journal. 2008;(4):70-71. (In Russ.)
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