Evaluation of molecular changes in the mucous membrane close to the resection margin after surgical treatment for gastric cancer
https://doi.org/10.34215/1609-1175-2020-4-73-75
Abstract
Objective: Secretion of the changes characterizing genetic instability of the gastric mucosa when having esophagus cancer.
Methods: 64 patients having esophagus cancer (main group) and 50 patients having gallstone disease were examined. They were undergoing treatment in the hospital No. 1 of the I.M. Sechenov First Moscow State Medical University. In all cases molecular tumor markers in the gastric mucosa after operation and biopsy were examined.
Results: Esophagus cancer turned out to be characterized by high frequency of RASSF1А and MLH1 genes methylation and high hTERT, MMP7 and BIRC5 genes expression, and also by high telomerase activity. There was also high frequency of TUSC3, CDH1 and DAPK genes methylation inside gastric mucosa approached to the edge of resection.
Conclusions: The study of the frequency of TUSC3, CDH1, DAPK, RASSF1А and MLH1 genes methylation and telomerase activity can be used as clinical markers defining changes in gastric mucosa after its resection concerning cancer.
About the Authors
I. V. Reshetov
I.M. Sechenov First Moscow State Medical University
Russian Federation
Russian Federation
MD, PhD, professor, member of the Russian Academy of Sciences, head of the Clinic for Oncology, Reconstructive Plastic Surgery and Radiology, head of the Department for Plastic Surgery,
8/2 Trubetskaya St., Moscow, 119991
I. I. Bykov
I.M. Sechenov First Moscow State Medical University
Russian Federation
Russian Federation
MD, PhD, Oncological Surgical Department of Combined Methods of Treatment of the Clinic for Oncology, Reconstructive Plastic Surgery and Radiology,
8/2 Trubetskaya St., Moscow, 119991
M. S. Mikerova
I.M. Sechenov First Moscow State Medical University
Russian Federation
Russian Federation
MD, PhD, associate professor, N.A. Semashko Department of Public Health and Healthcare,
8/2 Trubetskaya St., Moscow, 119991
M. V. Nemtsova
I.M. Sechenov First Moscow State Medical University
Russian Federation
Russian Federation
MD, PhD, professor, head of the Laboratory of Medical Genetics, Institute for Molecular Medicine,
8/2 Trubetskaya St., Moscow, 119991
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Review
For citations:
Reshetov I.V., Bykov I.I., Mikerova M.S., Nemtsova M.V. Evaluation of molecular changes in the mucous membrane close to the resection margin after surgical treatment for gastric cancer. Pacific Medical Journal. 2020;(4):73-75. (In Russ.) https://doi.org/10.34215/1609-1175-2020-4-73-75
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