The effectiveness of preventive anti-tuberculosis therapy for children with autoimmune systemic diseases
https://doi.org/10.34215/1609-1175-2021-1-34-36
Abstract
Objective: To estimate the effectiveness of the preventive tuberculosis treatment among children having autoimmune systemic diseases who get immunosuppressive therapy.
Methods: A cohort study of 59 participants under 17 years old was conducted. They got treatment for their rheumatic diseases in specialized medical institutions and were sent for phtisiatrician consultation because of the high risk of tuberculosis progression. Thanks to the doctor's scheme of actions and according to the screening results the preventive anti tuberculosis therapy was prescribed. Then the frequency of active tuberculosis progression was estimated.
Results: There is a high level of effectiveness of the preventive anti-tuberculosis measures among children who get immunosuppressive therapy: there were no cases of active tuberculosis.
Conclusions: Preventive anti-tuberculosis measures developed for children getting immunosuppressive drugs allow reducing the risk of active tuberculosis progression significantly.
About the Authors
A. V. Kazakov
National Medical Research Center of Phthisiopulmonology and Infectious Diseases; I.M. Sechenov First Moscow State Medical University; National Medical Research Center for Children’s Health
Russian Federation
Russian Federation
Alexey V. Kazakov, MD, PhD, senior researcher.
4/2 Dostoevskogo St., Moscow, 127473
E. K. Dementieva
National Medical Research Center of Phthisiopulmonology and Infectious Diseases
Russian Federation
Russian Federation
Elena K. Dementieva, MD.
4/2 Dostoevskogo St., Moscow, 127473
N. I. Klevno
National Medical Research Center of Phthisiopulmonology and Infectious Diseases; I.M. Sechenov First Moscow State Medical University
Russian Federation
Russian Federation
Nadezhda I. Klevno, MD, PhD, leading researcher of the Department of Child and Adolescent Tuber-culosis.
4/2 Dostoevskogo St., Moscow, 127473
A. D. Pakhlavonova
National Medical Research Center of Phthisiopulmonology and Infectious Diseases
Russian Federation
Russian Federation
Aziza D. Pakhlavonova, MD.
4/2 Dostoevskogo St., Moscow, 127473
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Review
For citations:
Kazakov A.V., Dementieva E.K., Klevno N.I., Pakhlavonova A.D. The effectiveness of preventive anti-tuberculosis therapy for children with autoimmune systemic diseases. Pacific Medical Journal. 2021;(1):34-36. (In Russ.) https://doi.org/10.34215/1609-1175-2021-1-34-36
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