Preview

Pacific Medical Journal

Advanced search

Questions of unification of preclinical diagnosis of myocardial damage among patients with combined cardiorespiratory pathology

https://doi.org/10.34215/1609-1175-2021-3-45-48

Abstract

Objective: The development of the way of diagnosing early damage of left ventricle (LV) of heart among smokers with early stages of the chronic obstructive pulmonary disease (COPD) and arterial hypertension (AH) by speckle-tracking of echocardiography using new indexes and possibility of its reproduction regardless the manufacturer of ultrasound scanner and its software.

Methods: 99 smokers 48.8 years old on average were observed. Patients were divided into four groups depending on the presence of COPD and AH. Strain-echocardiography with the estimate of the local and left ventricular global longitudinal strain was performed.

Results: Diastolic dysfunction of LV was defined during all observations, but it prevailed among patients having COPD and AH. Ventricular global and local longitudinal strains were within default values. The decrease in deformation of basal segments of LV among patients having COPD and AH was registered. Average value of the deformation in basal segments of LV turned out to be less among patients having AH regardless of existence of COPD.

Conclusions: Early signs of LV myocardial injuries among smokers are highly presented in case of COPD and AH. Both normal indexes of standard echocardiography and normal indexes of ventricular global and local longitudinal strains don’t exclude early myocardial damage. Relative indicators of ventricular longitudinal strains are more sensitive markers of myocardial damages among smokers in preclinical stage. Strain-echocardiography can be used as hardware-independent diagnostic method of the early signs of myocardial damage of LV. 

About the Authors

E. A. Kondrashova
Vladivostok Clinical Hospital No. 1; Pacific State Medical University
Russian Federation

MD, 22 Sadovaya St., Vladivostok, 690078;

assistant of the Institute of Therapy



V. A. Nevzorova
Pacific State Medical University
Russian Federation

MD, PhD, professor, head of the Institute of Therapy, 

2 Ostryakova Ave., Vladivostok, 690002



D. V. Kondrashov
Vladivostok Clinical Hospital No. 1; Pacific State Medical University
Russian Federation

student, 

92 Ostryakova Ave., Vladivostok, 690002



N. V. Shestakova
Pacific State Medical University
Russian Federation

MD, PhD, associate professor, Institute of Therapy, 

2 Ostryakova Ave., Vladivostok, 690002



References

1. Bogdanov DYu, Kondrashova EA, Kulakova NV, Shestakova NV, Mokshina MV, Martynenko IM. Risk factors’ characteristics of cardiovascular diseases in the population of primorsk region residents depending on the status of smoking and age (according to the data of the epidemiological study of ESSERF). Pacific Medical Journal. 2017;4:45–50 (In Russ).

2. Freixa X, Portillo K, Paré C, Garcia-Aymerich J, Gomez FP, Benet M, et al. Echocardiographic abnormalities in patients with COPD at their first hospital admission. Eur Respir J. 2013;41:784–91.

3. Barberà JA. Mechanisms of development of chronic obstructive pulmonary disease-associated pulmonary hypertension. Pulm Circ. 2013;3(1):160–4.

4. Phelan D, Collier P, Thavendiranathan P, Popović ZB, Hanna M, Plana JC, et al. Relative apical sparing of longitudinal strain using two-dimensional speckle-tracking echocardiography is both sensitive and specific for the diagnosis of cardiac amyloidosis. Heart. 2012;98(19):1442–8.

5. Senapati A, Sperry BW, Grodin JL, Paaladinesh KK, Jaber TW, Mazen PC, et al. Prognostic implication of relative regional strain ratio in cardiac amyloidosis. Heart. 2016;102:748–54

6. Lee VV, Timofeeva NYu, Zadionchenko VS, Adasheva TV, Vysotskaya NV. Recent aspects of cardiac remodeling in patients with chronic obstructive pulmonary disease. Rational Pharmacotherapy in Cardiology. 2018;14(3):379–86 (In Russ).

7. Voelkel NF, Mizuno S, Bogaard HJ. The role of hypoxia in pulmonary vascular diseases: A perspective. Am J Physiol Lung Cell Mol Physiol. 2013;304(7):L457–65.


Review

For citations:


Kondrashova E.A., Nevzorova V.A., Kondrashov D.V., Shestakova N.V. Questions of unification of preclinical diagnosis of myocardial damage among patients with combined cardiorespiratory pathology. Pacific Medical Journal. 2021;(3):45-48. (In Russ.) https://doi.org/10.34215/1609-1175-2021-3-45-48

Views: 300


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 1609-1175 (Print)