Biochemical markers influence of black shiksha juice (Empetrum nigrum) on the process of alloxan diabetes
https://doi.org/10.34215/1609-1175-2021-3-59-62
Abstract
Objective: The analysis of the pharmacotherapeutic effectiveness of Empetrum nigrum juice in case of diabetes mellitus (DM) in the experiment.
Methods: DM chemical model applying single alloxan injection (100 mg/kg) was used for rats of Vistar line weighing 280–320 grams. Experimental animal groups got Empetrum nigrum juice and standard antidiabetic drug – rutin (quercetin biglycoside). The level of glucosemia and alanine aminotransferase in blood serum was measured. The state of lipids peroxidation (by malonic dialdehyde) and antiradical activity index off-load and applying glucose-tolerance test was estimated.
Results: Hypoglycemic, antioxidant and pancreas-protective effect of Empetrum nigrum juice was defined.
Conclusions: Received data allows recommending further antidiabetic potential of Empetrum nigrum with the perspective of using it in the therapy of diabetes mellitus of the second type.
About the Authors
N. V. Plaksen
Pacific State Medical University
Russian Federation
Russian Federation
MD, PHD, associate professor,
2 Ostryakova Ave., Vladivostok, 690002
L. V. Ustinova
Pacific State Medical University
Russian Federation
Russian Federation
PhD (Pharmacy), associate professor, head of the Department of Pharmacy,
2 Ostryakova Ave., Vladivostok, 690002
S. G. Ponomarchuk
Pacific State Medical University
Russian Federation
Russian Federation
MD, senior lecturer, Department of Pharmacy,
165 Okeansky Ave., Vladivostok, 690002
L. N. Logunova
Pacific State Medical University
Russian Federation
Russian Federation
PhD (Pharmacy), associate professor, Department of Pharmacy,
2 Ostryakova Ave., Vladivostok, 690002
O. N. Li
Pacific State Medical University
Russian Federation
Russian Federation
MD, PhD, professor, Department of General and Clinical Pharmacology,
2 Ostryakova Ave., Vladivostok, 690002
E. A. Motlukh
Pacific State Medical University
Russian Federation
Russian Federation
MD, assistant,
2 Ostryakova Ave., Vladivostok, 690002
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Review
For citations:
Plaksen N.V., Ustinova L.V., Ponomarchuk S.G., Logunova L.N., Li O.N., Motlukh E.A. Biochemical markers influence of black shiksha juice (Empetrum nigrum) on the process of alloxan diabetes. Pacific Medical Journal. 2021;(3):59-62. (In Russ.) https://doi.org/10.34215/1609-1175-2021-3-59-62
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