Preview

Pacific Medical Journal

Advanced search

Pituicytoma: A clinical case of hormonally inactive pituitary macroadenoma with chiasma compression

https://doi.org/10.34215/1609-1175-2024-2-65-69

Abstract

In the article, a clinical case of a hormonally inactive tumor of the posterior pituitary is described. The clinical symptoms were caused by mass effect (chiasma compression and hypopituitarism). Transnasal transsphenoidal adenomectomy was performed on the patient. Subsequent morphologic examination revealed a solid neoplasm of large cells with broad oxyphilic granular cytoplasm, presumably originating from adenohypophysis cells. By immunohistochemical examination, pituicytoma, a granular cell tumor of the posterior pituitary, was diagnosed. Hence, the significance of differential diagnostics of pituicytoma is indicated, including clinical and hormonal manifestations, as well as pathomorphologic analysis data.

About the Authors

L. K. Dzeranova
Endocrinology Research Centre
Russian Federation

Moscow



N. S. Skrundik
Endocrinology Research Centre
Russian Federation

Moscow



A. M. Lapshina
Endocrinology Research Centre
Russian Federation

Moscow



E. A. Pigarova
Endocrinology Research Centre
Russian Federation

Moscow



A. G. Kuzmin
Endocrinology Research Centre
Russian Federation

Moscow



S. Yu. Vorotnikova
Endocrinology Research Centre
Russian Federation

Svetlana Y. Vorotnikova, Cand. Sci. (Med.), Associate Professor Department of Endocrinology, Institute of Education

11 Dmitriya Ul’yanova st., Moscow, 117292

+7 (926) 840-22-44



V. N. Azizyan
Endocrinology Research Centre
Russian Federation

Moscow



A. S. Shutova
Endocrinology Research Centre
Russian Federation

Moscow



References

1. Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, Burger PC, Jouvet A, Scheithauer BW, Kleihues. Th e 2007 WHO classifi cation of tumors of the central nervous system. Acta Neuropathol. 2007; 114(2):97–109. doi: 10.1007/s00401-007-0243-4

2. Brat DJ, Scheithauer BW, Staugaitis SM, Holtzman RN, Morgello S, Burger PC. Pituicytoma: a distinctive low-grade glioma of the neurohypophysis. Am J Surg Pathol. 2000;24(3):362–8. doi: 10.1097/00000478-200003000-00004

3. Louis DN, Perry A, Reifenberger G, Deimling A, FigarellaBranger D, Cavenee WK, Ohgaki H, Wiestler OD, Kleihues P, Ellison DW. Th e 2016 World Health Organization classifi cation of tumors of the central nervous system: a summary. Acta Neuropathol. 2016;131(6):803–20. doi: 10.1007/s00401-016-1545-1

4. Kalinin PL, Fomichev DV, Chernov IV, Kutin MA, Shkarubo AN, Ismailov DB, Ryzhova MV. Endoscopic endonasal removal of pituicytomas and spindle cell oncocytomas. Russian Journal of Neurosurgery. 2018;20(1):21–32 (In Russ.)]. doi: 10.17650/1683-3295-2018-20-1-21-32

5. Brandão RA, Braga MH, Alves de Souza A, Reis BL, Faraj de Lima FB. Pituicytoma. Surg Neurol Int. 2010;1:79. doi: 10.4103/2152-7806.73802

6. Wei LD, Li C, Li D, Liu XJ, Li RT, Li LW, Wang JM, Zhou DB. Treatment and prognostic factors of pituicytoma: a single-center experience and comprehensive literature review. Pituitary. 2021;24(5):754–67. doi: 10.1007/s11102-021-01152-5

7. Cheng JH, Nie D, Li B, Gui SB, Li CZ, Zhang YZ, Cavallo LM, Zhao P. Clinical features, radiological profi les, pathological features and surgical outcomes of pituicytomas: a report of 11 cases and a pooled analysis of individual patient data. Mil Med Res. 2021;8(1):39. doi: 10.1186/s40779-021-00332-5

8. Shah B, Lipper MH, Laws ER, Lopes MB, Spellman MJ. Jr. Posterior pituitary astrocytoma: a rare tumor of neurohypophysis: a case report. AJNR Am J Neuroradiol 2005;26(7):1858–61.

9. Takei Y, Seyama S, Pearl GS, Tindall GT. Ultrastructural study of the human neurohypophysis cellular elements of neural parenchyma, the pituicytes. Cell Tissue Res. 1980;205(2):273–87. doi: 10.1007/BF00234685

10. Chen B, Fan X, Zhang Z. Pituicytoma: Report of three cases and a systematic literature review. Clin Neurol Neurosurg. 2021;205:106650. doi: 10.1016/j.clineuro.2021.106650


Review

For citations:


Dzeranova L.K., Skrundik N.S., Lapshina A.M., Pigarova E.A., Kuzmin A.G., Vorotnikova S.Yu., Azizyan V.N., Shutova A.S. Pituicytoma: A clinical case of hormonally inactive pituitary macroadenoma with chiasma compression. Pacific Medical Journal. 2024;(2):65-69. (In Russ.) https://doi.org/10.34215/1609-1175-2024-2-65-69

Views: 348


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 1609-1175 (Print)