Application of prolonged veno-venous hemodiafiltration in intensive care for patients with severe thermal injuries
P. A. Griban,
K. V. Maystrovskiy,
V. V. Usov,
O. E. Orobiy,
A. A. Polezhaev,
T. N. Obydennikova,
S. M. Terehov,
E. E. Kostiva https://doi.org/10.34215/1609-1175-2025-2-86-91
Abstract
Burn disease in the stage of acute burn toxemia represents a symptom complex of interrelated and mutually aggravating pathological conditions, which can be appropriately grouped under the term "syndrome of mutual burdening". This primarily includes systemic inflammatory response syndrome (SIRS) characterized by severe endotoxemia, immunosuppression, and hypermetabolic syndrome. One of the key components of multimodal treatment for severe thermal injury is the implementation of comprehensive detoxification therapy, which makes it possible to prevent the development of burn disease complications and improves the overall prognosis. The use of hemodiafiltration procedures in patients during the burn toxemia stage leads to significant improvements in hemodynamics, pulmonary oxygenation, and correction of pathological disturbances in homeostasis. The obtained data demonstrate new possibilities in the intensive care of patients with deep burns. Incorporating hemodiafiltration into the treatment protocol may reduce mortality and shorten the duration of hospitalization
About the Authors
P. A. Griban
Far-Eastern District Medical Center of Federal Medical Biological Agency; Pacific State Medical University; Far-Eastern Federal University, School of Medicine
Russian Federation
Russian Federation
Pavel Andreevich Griban – Dr. Sci. (Med.), Surgeon; Associate Professor at the Institute
of Surgery
K. V. Maystrovskiy
Far-Eastern District Medical Center of Federal Medical Biological Agency; Far-Eastern Federal University, School of Medicine
Russian Federation
Russian Federation
V. V. Usov
Far-Eastern District Medical Center of Federal Medical Biological Agency; Far-Eastern Federal University, School of Medicine
Russian Federation
Russian Federation
O. E. Orobiy
Far-Eastern District Medical Center of Federal Medical Biological Agency
Russian Federation
Russian Federation
A. A. Polezhaev
Far-Eastern District Medical Center of Federal Medical Biological Agency; Pacific State Medical University
Russian Federation
Russian Federation
T. N. Obydennikova
Far-Eastern District Medical Center of Federal Medical Biological Agency; Pacific State Medical University
Russian Federation
Russian Federation
S. M. Terehov
Far-Eastern District Medical Center of Federal Medical Biological Agency
Russian Federation
Russian Federation
E. E. Kostiva
Pacific State Medical University
Russian Federation
Russian Federation
References
1. Alexeev AA, Bobrovnikov AE, Malyutina NB, Filimonov KA. Analysis and features of the work of burn hospitals of the Russian Federation in 2022. Combustiologia. 2023;69–70 (In Russ.) URL: http://combustiolog.ru (Accessed Feb 03, 2025).
2. Peck MD, Toppi JT. Epidemiology and Prevention of Burns Throughout the World. In: Jeschke MG, Kamolz L-P, Sjöberg F, Wolf SE, editors. Handbook of burns. Voume.1. Cham, Springer. 2020;17-57.
3. Burn Incidence and Treatment in the United States: 2016. American Burn Association. 2017. URL: http://ameriburn.org/who-we-are/media/burn-incidence-fact-sheet/ (Accessed Feb 02, 2025)
4. Zinoviev EV, Manukovskiy VA, Zavorotniy OO, Kostyakov DV. Analysis of the features of the course of burn injury, taking into account the value of the severity index of the lesions. The Journal of EMERGENCY SURGERY named after I.I. Dzhanelidze. 2023;1(10):32–9 (In Russ.) doi: 10.54866/27129632-2023-1-31
5. Griban PA, Terehov SМ, Maystrovskiy KV, Usov VV, Polezhaev AA, Protopopov VV, Sotnichenko SA, Bogdanov VA. Treatment of patients with major burn injury in the Burn Unit, Far Eastern District Medical Center of Federal Medical Biological Agency, Russia. Pacific Medical Journal. 2023;2:89–93 (In Russ.) doi: 10.34215/1609-1175-2023-2-89-93
6. Presnyakova MV, Arefiev IYu, Galova EA, Krestova EI, Kostina OV. The significance of biological markers of endotheliopathy in the development of “early” sepsis in severely burned patients. Klinicheskaya Laboratornaya Diagnostika (Russian Clinical Laboratory Diagnostics). 2024;69(6):257–64 (In Russ.) doi: 10.51620/0869-2084-2024-69-6-257-264
7. Alp E. Risk factors for nosocomial infection and mortality in burn patients: 10 years of experience at a university hospital. J. Burn Care Res. 2012;33(3):379–85
8. Sherren PB, Hussey J, Martin R, Kundishora T. Lethal triad in severe burns. Burns. 2014;40(8):1492–6.
9. Lu RP, Ni A, Lin FC, Ortiz-Pujols SM, Adams SD, Monroe DM 3rd, Whinna HC, Cairns BA, Key NS. Major burn injury is not associated with acute traumatic coagulopathy. J Trauma Acute Care Surg. 2013;74(6):1474–9. doi: 10.1097/TA.0b013e3182923193
10. Ronco C, Bellomo R, Homel P, Brendolan A, Dan M, P Piccinni P, La Greca G. Effects of different doses in continuous veno-venous haemofiltration on outcomes of acute renal failure: a prospective randomised trial. Lancet. 2000;356(9223):26–30. doi: 10.1016/S0140-6736(00)02430-2
11. Borthwick EM, Hill CJ, Rabindranath KS, Maxwell AP, McAuley DF, Blackwood B. High-volume haemofiltration for sepsis in adults. The Cochrane database of systematic reviews. 2017;1:1–39. doi: 10.1002/14651858
12. Chung KK, Coates EC, Smith DJ Jr, Karlnoski RA, Hickerson WL, et al. Randomized controlled Evaluation of high-volume hemofiltration in adult burn patients with Septic shoCk and acUte kidnEy injury (RESCUE) Investigators. High-volume hemofiltration in adult burn patients with septic shock and acute kidney injury: a multicenter randomized controlled trial. Crit Care. 2017;21(1):289. doi: 10.1186/s13054-017-1878-8
Review
For citations:
Griban P.A., Maystrovskiy K.V., Usov V.V., Orobiy O.E., Polezhaev A.A., Obydennikova T.N., Terehov S.M., Kostiva E.E. Application of prolonged veno-venous hemodiafiltration in intensive care for patients with severe thermal injuries. Pacific Medical Journal. 2025;(2):86-91. (In Russ.) https://doi.org/10.34215/1609-1175-2025-2-86-91
Views:
13
Email this article 