The analysis of indicators of matrix metal proteinases and their inhibitors before and after the dental implantation
Abstract
Background. An important aspect of occurrence of early complications of dental implantation and inflammation in the implantation area is integrity of a connecting tissue surrounding it while its injury influences the balance of the tissue metalloproteinase-1 inhibitor (TIMP1) and matrix metalloproteinase (MMPs) 8 and 9. Methods. 80 patients at the age of 30-60 years old who underwent dental implantation were examined. In 70 cases the postoperative period had no complications (1st group); at 10 cases there were early complications - an edema and hyperemia of the soft tissues (2nd group). In blood and the mixed oral liquid the levels of MMP-8, MMP-9 and TIMP1 were determined. For the control authors investigated the blood and the oral liquid of 20 practically healthy people. Results. Statistically significant increase of the systemic level of ММР-8 is revealed, MMP-9 and TIMP1 has been considerably raised at patients of 2nd group. At patients with not complicated postoperative period local and systemic increase of concentration of MMP-9 and local increase of concentration of TIMP1 is found. Conclusions. Studying of qualitative and quantitative characteristics of ММРs and their inhibitors is a perspective direction of basic researches which will allow developing the new approaches to diagnostics and treatment of complications at dental implantation.
About the Authors
Yu. V. Yugai
Pacific State Medical University
Russian Federation
Russian Federation
A. A. Golitsyna
Pacific State Medical University
Russian Federation
Russian Federation
V. E. Tolmachyov
Pacific State Medical University
Russian Federation
Russian Federation
E. V. Markelova
Pacific State Medical University
Russian Federation
Russian Federation
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Review
For citations:
Yugai Yu.V., Golitsyna A.A., Tolmachyov V.E., Markelova E.V. The analysis of indicators of matrix metal proteinases and their inhibitors before and after the dental implantation. Pacific Medical Journal. 2014;(3):65-67. (In Russ.)
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