Deferoxamine in the prevention of endothelial reperfusion injuries in case of experimental ischemia/reperfusion

Abstract

15-minute ischemia and 15-minute intestinal reperfusion have been simulated to analyse the pathogenetic importance of the impaired iron exchange in forming endothelial dysfunction during the reperfusion in the experiment on 40 ‘Vistar’ male rats. The authors studied the central hemodynamics indices, blood viscosity, content of transferrin, ferritin, serum iron and von Willebrand factor, and revealed that during the reperfusion the transferrin content decreased, the ferritin content and the von Willebrand factor increased, and there were disturbances in the rheological properties of blood with the tendency towards the decrease in the cardiac index and total peripheral vascular resistance. The preliminary infusion of deferoxamine allowed recovery of the transferrin content, decrease of the ferritin level, normalisation of the blood rheology and hemodynamics indices. This appeared to result in the reduction of the endothelial destruction due to reducing content of Fe2+ in blood serum. As a conclusion, the preliminary infusion of deferoxamine allows efficiently prevent the endothelium injuries during the reperfusion under critical conditions.