Role of systemic endothelial dysfunction in the progress of lung hypertension in children with chronic bronchopulmonary pathology

Abstract

The authors have examined 180 healthy children and 359 children with severe bronchial asthma associated with bronchiectasis and hypersensitive pneumonitis in an effort to study the endothelial vasomotor function by measuring brachial artery response on the reactive hyperaemia. The maximum endothelium-dependent vasodilatation in patients with pulmonary hypertension was reliably lesser than that of the healthy people. The total endothelium-dependent vasodilatation and the coefficient of endothelial sensitivity to shift tension in patients with the lung hypertension were reliably lesser than those of the patients with normal pressure in the lung artery and healthy children. The authors found out the negative correlation of the endothelium-dependent vasodilatation with average pressure in the lung artery and revealed that the functional state of the endothelium has had the important role in the pathogenesis of the lung hypertension, irrespective of the type of the disease. As reported, the risk factors for the lung hypertension in children with the chronic bronchopulmonary pathology include the value of the maximum endothelium-dependent vasodilatation of less than 10%, the index of the total endothelium-dependent vasodilatation of less than 850 %-с, the value of the coefficient of the endothelial sensitivity to the shift tension of less than 25.