Comorbidity structure in psoriasis patients according to dermatology department data
https://doi.org/10.34215/1609-1175-2024-2-33-36
Abstract
Aim. An analysis of the structure of concomitant pathology in patients with widespread psoriasis vulgaris.
Materials and methods. An open, uncontrolled, single-center retrospective study of the case histories of 100 patients with widespread plaque psoriasis who received medical care in a dermatology department of Irkutsk State Medical University clinics was carried out. Concomitant pathology was established on the basis of anamnesis and physical examination, as well as laboratory tests and consultations with a physician and related specialists.
Results. Diseases of the gastrointestinal tract accounted for 81%, of which non-alcoholic fatty liver disease was detected in 43%. Endocrinopathies were noted in 72% of patients, a third (30%) had obesity of varying degrees, and 14% had type 2 diabetes mellitus. Pathologies of the circulatory system was diagnosed in 34% of patients, including hypertension in 29%. Psoriatic arthritis was detected in 11% of cases. In patients under 40 years of age, an average of 1–2 comorbid conditions were noted, while the number of concomitant diseases increased to 4–5 by the age of 60. Only 17% of the patients had no comorbidities.
Conclusions. In the majority of patients, psoriasis is associated with certain diseases, being a harbinger of their development. This fact should be taken into account when determining personalized treatment tactics.
About the Authors
E. A. TrapeznikovaRussian Federation
Ekaterina A. Trapeznikova, resident of the Department of dermatovenerology and cosmetology
1 Krasnogo Vosstaniya St., Irkutsk, 664003
+7 (904) 113-88-38
A. I. Yakubovich
Russian Federation
Irkutsk
E. G. Gaydarova
Russian Federation
Irkutsk
References
1. Kubanov AA, Ed. Psoriasis. Clinical guidelines. Moscow; 2023; 78 p. (In Russ.)].
2. Oganov RG, Simanenkov VI, Bakulin IG, Bakulina NV, Barbarash OL, Boytsov SA, Boldueva SA, Garganeeva NP, Doshchitsin VL, Karateev AE, Kotovskaya YuV, Lila AM, Lukyanov MM, Morozova TE, Pereverzev AP, Petrova MM, Pozdnyakov YuM, Syrov AV, Tarasov AV, Tkacheva ON, Shalnova SA. Comorbidities in clinical practice. Algorithms for diagnostics and treatment. Cardiovascular Therapy and Prevention. 2019;18(1):5–66 (In Russ.)]. doi: 10.15829/1728-8800-2019-1-5-66
3. Ufimtseva MA, Popov AA, Fedotova LV, Mylnikova ES, Bochkarev YuM, Zhunisova DS. Psoriasis and metabolic syndrome: a review. Obesity and Metabolism. 2020;17(4):369–74 (In Russ.)]. doi: 10.14341/omet12517
4. Yamazaki F. Psoriasis: Comorbidities. J Dermatol. 2021;48(6):732– 40. doi: 10.1111/1346-8138.15840
5. Daugaard C, Iversen L, Hjuler KF. Comorbidity in Adult Psoriasis: Considerations for the Clinician. Psoriasis (Auckl.). 2022; 12: 139–50. doi: 10.2147/PTT.S328572
6. Raharja A, Mahil SK, Barker JN. Psoriasis: a brief overview. Clin Med (Lond). 2021;21(3):170–3. doi: 10.7861/clinmed.2021-0257
7. Amin M, Lee EB, Tsai TF, Wu JJ. Psoriasis and Co-morbidity. Acta Derm Venereol. 2020;100(3):adv00033. doi: 10.2340/000155553387
8. Kras’ko OV, Ed. Statistical analysis of data in medical research: in 2 parts. Part I. Minsk, MSEU named aft er A.D. Sakharov, 2014, 127 p. (In Russ.)].
9. Egeberg A, Gisondi P, Carrascosa JM, Warren RB, Mrowietz U. Th e role of the interleukin-23/Th 17 pathway in cardiometabolic comorbidity associated with psoriasis. J Eur Acad Dermatol Venereol. 2020;34(8):1695–706. doi: 10.1111/jdv.16273
10. Takeshita J, Grewal S, Langan SM, Mehta NN, Ogdie A, Van Voorhees AS, Gelfand JM. Psoriasis and comorbid diseases: Epidemiology. J Am Acad Dermatol. 2017;76(3):377–90. doi: 10.1016/j.jaad.2016.07.064
11. Kubanov AA, Bogdanova EV. Epidemiology of psoriasis in the Russian Federation according to the patient registry. Vestnik Dermatologii i Venerologii. 2022;98(1):33–41 (In Russ.)]. doi: 10.25208/ vdv1268
12. Kimball AB, Leonardi C, Stahle M, Gulliver W, Chevrier M, Fakharzadeh S, Goyal K, Calabro S, Langholff W, Menter A. PSOLAR Steering Committee. Demography, baseline disease characteristics and treatment history of patients with psoriasis enrolled in a multicentre, prospective, disease-based registry (PSOLAR). Br J Dermatol. 2014;171(1):137–47. doi: 10.1111/bjd.13013
13. Iskandar IY, Ashcroft DM, Warren RB, Yiu ZZ, McElhone K, Lunt M, Barker JN, Burden AD, Ormerod AD, Reynolds NJ, Smith CH, Griffiths CE. Demographics and disease characteristics of patients with psoriasis enrolled in the British Association of Dermatologists Biologic Interventions Register. Br J Dermatol. 2015;173(2):510–8. doi: 10.1111/bjd.13908
Review
For citations:
Trapeznikova E.A., Yakubovich A.I., Gaydarova E.G. Comorbidity structure in psoriasis patients according to dermatology department data. Pacific Medical Journal. 2024;(2):33-36. (In Russ.) https://doi.org/10.34215/1609-1175-2024-2-33-36