The article is devoted to a new scientific direction - development of systems for the specific delivery of proteins, nucleic acids and polysaccharides through tissue barriers. Attention is given to natural, non-toxic compounds constituting a group of carbohydrate biopolymers. The paper also describes the structure, physicochemical properties and pharmacological activity of pectins, alginates, chitosans, carrageenans, fucoidans and micro- and nanosystems based on these compounds. The author gives examples of the use of chitosan nanoparticles for enteral introduction of hormones, genes erythropoietin and heparin. The emphasis is put on the necessity for toxicological studies of new drug dosage forms.

Review of the literature devoted to venous thromboembolic complications after total knee joint arthroplasty, the risk factors of these complications, as well as their relationship with osteoporosis. The research gives analysis of publications devoted to the study of hyperhomocysteinemia as predictor of thrombosis, as well as a marker for osteoporosis. It also provides explanation to the relationship to increase the frequency of venous thromboembolic complications with decreased bone density. The authors hypothesized pathogenetic role of homocysteine in the development of thromboembolism in patients with uncomplicated osteoporosis. It is necessary to study homocysteine levels in the blood of patients undergoing knee arthroplasty, in order to identify the correlation between the incidence of venous thromboembolic complications and decrease in bone mineral density.

The plants growing in the Primorsky Territory are widely used in modern medicine. Traditional medicine uses xylo-phytes and herbaceous native species of plants. Methods. The researchers determined the content of some trace elements in higher wild plants collected in the Primorsky Territory: Dahurian rose, Schizandra chinensis, spiny Eleuterococcus, celandine Asian, plantain Asian. Results. Iron and aluminium dominated by the concentration level in all plant organs. The highest content of barium noted in plantain leaves and Eleuterococcus roots, iron and manganese - in rose hips and Schizandra, zinc - in the plantain aerial part, in flowers and fruits of celandine, copper - in the generative organs of herbaceous plants, the fruits of Schizandra. Higher concentrations of lead and cadmium found in herbaceous plants. The concentration of arsenic exceeded the element’s known proportion for terrestrial plants by 4-12 times. Selenium concentration in the plants from the central districts of Primorsky Territory was significantly higher than described optimum level. Conclusions. The common law confirmed for the researched plants: the concentration levels of essential elements in the organs were higher than the poportion of elements revealing toxic properties. The concentration of the latter did not exceed hygienic standards. Thus, plants growing in the Primorsky Territory can be used as a crude drug.

The research work is devoted to the study of macro-and microscopic diagnostic features of patrinia rupestris raw material. Methods. Raw materials were the dried leaves of P. rupestris. The work investigated the leaf drugs from the surface, in accordance with conventional techniques using microscope Axio Scope A1 as well as formation system and Axio Vision 4.7.2 image analysis. Results. Typical diagnostic features of P. rupestris leaves are: singlerow combined epidermis, the ratio of the longitudinal and transverse dimensions of its cells, anomocyte type of stomata complex on the abaxial side, bicellular pachypleurous cone-shaped hairs with wartlike cuticle rugosity, idioblast. Conclusions. The study reveals a number of macro- and microscopic diagnostic features for raw P. rupestris. Some have high variability, while others are stable and allow to determine conclusively the originality of herbal raw materials used.

The article is devoted to experimental evaluation of the impact of peripherically-induced neuroinflammation on the severity of cognitive impairment, depending on age. Methods. Neuroinflammation has been induced in the 3- and 18-month-old white male mice with an intraperitoneal injection of bacterial lipopolysaccharides Escherichia coli 0111: B4 (Sigma Aldrich) 5 mg/kg. After 24 hours, the researchers determined locomotor activity and a working memory in Y-maze. Then the test animals were taken out of the experience and assessed the expression of the proteins GFAP and OX-42 on transverse hippocampal sections. Results. In 18-month-old mice there have been revealed more severe cognitive deficit and decreased locomotor activity compared with the group of “young” test animals. Immunohistochemical methods in hippocampus of 18-month-old mice showed more pronounced activation of microglia and astrogliosis. Conclusions. Aging is accompanied by increased tendency to neuroinflammation. Stimulation of the immune system by bacterial endotoxin increases the severity of inflammatory reactions in the brain of aged mice compared to young animals, regularly provoking neurodegeneration and cognitive deficit.

The paper gives the analysis of the chemical composition of raw materials and extracts of the root and aboveground parts of Patrinia rupestris, potentially having neurotropic activity. Methods. Raw herbs and roots were procured at the flowering stage (in August). The researchers used standard methods. Results. Content of secondary metabolites was higher in the raw herb, in the roots it exceeded analogous proportion of polysaccharides by 82.5 %, tannins - 34.7 %, pectins - 61.1 %, catechins -224.9 %, carotenes - 20.4 %. Flavonol content in the herb exceeded that of the root part by 12.2 times. The extracts were water-soluble components: polysaccharides, flavonols, tannins. Conclusions. Raw root and aboveground parts of P. rupestris contains the same biologically active substances with the number of secondary metabolites in raw root is significantly smaller than that of the raw herb.

In view of the fact that the problem of stress is important, search of drugs with anti-stress effect is becoming an urgent thing. The source of such drugs can be phytogenic raw materials. Methods. The article considers the extractions out of more than 200 species of the Far Eastern plants. The researchers caused stress by immobilization of test animals (mice) treated with the extracts studied. Manifestations of stressing effects were analyzed on the basis of change in the mass of the adrenal glands, thymus and spleen, as well as the severity of erosive and ulcerative lesions of the gastrointestinal tract. Results. The research involves 10 species of plants, the extracts of which showed the greatest anti-stress effect. Conclusion. The most anti-stress activity is typical of Bergenia pacifica Kom., Aconitum volubile Pall., Manchurian walnut (Juglans mandshurica Maxim.), Schisandra chinensis Turcz., Lespedeza bicolor Turcz., Spiny Eleuterococcus (Eleutherococcus senticosus Maxim.), Amur grape (Vitis amurensis Rupr.), Dictamnus dasycar-pus Turcz., Amur lilac (Syringa amurensis Rupr.) and Manchurian Aralia (Aralia mandshurica Rupr. et Maxim.).

Background. The article considers the possibility of distinguishing the electroencephalogram (EEG) patterns associated with real and imagined movements by the right hand fingers with the support vectors method (SVM) for use in the development of the «brain-computer» interface. Methods. Six healthy subjects performed the real and imaginary pressing by the thumb and forefinger of the right hand. The researchers analyzed EEG sensorimotor cortex (C3 and Cz) in the time window 1600 ms after 750 ms from the beginning of the test. Indications for the classification were generated according to the 1^st trial signals and when summing up 3, 5, 10 and 20 trials of the same type. For classification were applied linear SVM and SVM based on radial basis function. Results. The average accuracy of movements classification exceeded statistically random threshold and increased with the number of trials (average 44.7±11.4 % when summing up 20 trials). Maximum classification accuracy using a linear SVM was 58.1±5.5 %, RBF SVM - 57.8±5.8 %. Recognition accuracy by 1 and 20 trials for SVM based on radial basis function was higher than that for the linear SVM. Conclusions. The authors show the possibility of distinguishing between EEG patterns of imagined movements by one hand fingers using SVM-classifier.

The research of pharmaceutical market of the antimicrobials (AM) is an important part for the treatment quality control of infections and prophylaxis of the antibiotic resistance. Methods. The authors have carried out ABC analysis of the AM market in Khabarovsk for the years 2009-2012. Results. The analysis found 337 items of AM making 67 international nonproprietary names. Conclusions. The largest share of sales of the AM were macrolides and lincosamides (J01F), beta-lactam antibiotics - penicillins (J01C) and antimicrobials - quinolone derivatives (J01M). Among international nonproprietary names the major were azithromycin, amoxicillin and amoxicillin-clavulanate, which came into Group A according to ABC analysis.

One of the urgent problems of modern pharmacology is the development of high-efficiency low-dose analgesics. Promising direction is the development of drugs based on the diterpene alkaloids produced by Ranunculaceous family plants. Methods. For the experimental study of the analgesic activity of a standardized alkaloid-containing aconite extract (Aconitum Kuznezoffi Reichenb. - Ranunculaceae Juss.) the researchers used screening models of thermic (Hot plate) and chemical (Abdominal constriction test) impact of pain. Results. In the test “hot plate” there was revealed a pronounced analgesic effect of the Aconitum Kuznezoffi Reichenb. in intragastric course use. On the model of chemical pain stimulation in the peritoneum the phyto-drug showed analgesic activity comparable with the effect of indometacin. Conclusions. Aconite extract showed a mixed type of receptor response on the models with different profile of pain stimulation that allows to include it into a group of promising highly active analgesics with a complex mechanism of action.

Cichorium is effective for gastrointestinal diseases, also has a hypoglycemic effect. The optical properties of the extract phytodrugs have been little studied, although they may serve as a test assessing their qualities. The purpose of the research - is a determination of spectrophotometric parameters of the extracts from chicory, production pieces of its dry extracts and comparison with other inulin-containing plants. Methods. The researchers used Cichorium intybus, dry extracts from its roots produced in Russia and India, Helianthus tuberosus and Taraxacum of ficinale Wigg. Absorption optical spectra (AOS) were recorded on a digital spectrophotometer UV-2051PC. Results. There were obtained normalized AOS of infusions and tinctures of Helianthus tuberosus, dandelion roots, roots, leaves, flowers, seeds and production pieces of dry extracts of Cichorium roots. Conclusions. AOS of infusions in the subsoil parts of Cichorium, Jerusalem artichoke and dandelion are similar that indicate their commonality of substances. AOS of Cichorium roots extracts produced in Russia and India are the same indicating the identity of the substances in the final products. AOS of dry extracts solutions and infusions of Cichorium roots extracts roots are considerably different. Probably, when producing dry extracts from Cichorium roots, the substances ensuring the availability of spectral peaks are reacted, and the chemical composition is distorted.

Among the potential bipolar analgesics the imidazoline receptor stimulants are currently under consideration, their effect probably simulates the one of certain endogenous agonist, the most likely candidate for the role of which is a polyamine agmatine. Methods. In the experiment on nonlinear male rats during intraperitoneal introduction the researchers examined the agmatine sulphate effect on the severity of pain sensitivity and nociceptive threshold parameters on the model of tonic inflammatory pain. After taking the animals out of the experience the researchers using the method of high-performance liquid chromatography determined the agmatine content in different parts of the brain and in the cerebrospinal fluid. Results. Introduction of agmatine sulphate in the dose of 50, 100 and 200 mg/kg has reduced the severity of pain, mainly, at the tonic pain stage. Introduction of agmatine to the intact animals did not change the initial threshold of the temperature pain sensitivity but increased activity of «analgesia caused by pain.» After injection the drug accumulates in the spinal cord, brain and cerebrospinal fluid. Conclusions. Agmatine anti-algetic effect, probably, is due to its effect on the activity of different signaling mechanisms of the central nervous system, particularly the system of nitric oxide synthesis. The presence of the drug after intraperitoneal introduction in different parts of the brain indicates its ability to break the blood-brain barrier. This fact, along with the results of testing the agmatine biological activity allows to consider agmatineergic system of the brain as a potential target of analgesics.

Considering the role of carotenoids in the physiological processes, an urgent issue for the modern pharmaceutical science is providing preventive medicines based on these elements. In this connection it is interesting to study the carotenoid content in the needles of various representatives of alien and native conifers in Primorsky region. Methods. To assess the conifers’ biological potential in terms of the source of carotenoids the authors studied the annual dynamics in magnification of these pigments in the two-year needles of 17 conifers growing in the arboretum at Gornotaezhnaya station of FEB RAS. The number of carotenoids was determined by spectrophotometry. Results. Analysis of the magnification of carotenoids in the two-year needles of native species allows to select the conifers with high content of the researched pigment: Japanese red pine - 0.32 mg/g, Korean pine - 0.29 mg/g, Labrador pine - 0.29 mg/g, Colorado spruce - 0.28 mg/g, needle fir, Siberian cedar, Koyama spruce, Ajan spruce - 0.27 mg/g of green weight each. Conclusions. The data received expand understanding of the carotenoids synthesis of conifers as well as possibilities of using needles as an additional source of vitamins, food supplements and colorings.

Helicobacter pylori is the cause of chronic gastritis, one of the most important factors in the pathogenesis of gastric ulcer and duodenal ulcer, MALT- lymphoma and gastric cancer. Methods. The research covers the effect of calcium pectate with the content of anhydrogalacturonic acid of 67.3 % and calcium - 38 mg/g of the sample with a degree of etherification of - 1.2 %, molecular weight - 39.3 kDa on H. pylori culture growth. Results. The paper reveals the decrease of amount of the grown colonies using calcium pectate in concentrations of 2 and 4 % in 48 and 72 hours, being more pronounced when using a polysaccharide in a concentration of 2 %. Conclusions. The data suggest the practical application of calcium pectate as anti-Helicobacter pylori effect in combined therapy of acid-related diseases associated with H. pylori.

Promising direction for correction of lipid peroxidation of biological membranes induced by thermal effect is the use of drugs on the basis of succinic acid, which, being an antioxidant, inhibits the activity of free radicals. Methods. In the course of experiment on rats for 21 days the researchers have been studied the possibility of correction of pro-oxidant effect of high temperatures by means of introduction of succinate containing drug “Remaxol” (STPC “Polysan”, St. Petersburg) in a dose of 100 mg/kg. Results. Thermal effect activated lipid peroxidation, reducing the activity of the body antioxidant system. Under these conditions, remaxol provided expressed antioxidant effect that has been indicated by reduction of blood peroxidation products and the increase in the activity of components of the antioxidant system. Conclusions. The study indicated remaxol to be reasonably recommended as an antioxidant, as well as the organism adaptive reactions regulator at high temperatures.

Ovarian dysfunction in perimenopause is characterized by increased level of follicle-stimulating hormone. Estrogens and progesterone, in turn, are able to interact with macrophages through their receptors to the steroid hormones. Methods. The authors studied the effect of iodide-bromine baths on the stability status of lysosomal membrane blood monocytes and peritoneal macrophages, secretory synthetic activity of these cells in 39 women of 45-52 years old: 16 healthy (control) and 23 with vegetative climacteric syndrome treated with iodide-bromine baths. Results. The women of the second group have been registered with labialization of lysosomal macrophages membranes, increasing their secretion of lysozyme while reducing its synthesis. Use of iodide-bromine baths led to the stabilization of these indicators and contributed disappearance or reduction of climacteric syndrome. Conclusions. The data obtained allow to expand the understanding of the mechanisms of action of balneotherapy on macrophage cells and conclude that the course application of iodide-bromine baths not only reduces the intensity of the symptoms of the climacteric syndrome, but also makes adjustments to the immune system in perimenopause.

The number of plants having a hepatoprotective effect includes Kamchatka Bilberry - Vaccinium praestans, Ericaceae, not included in the state pharmacopoeia, though it has been used in folk medicine for a long time. Methods. In the experiment the scholars were simulating toxic hepatitis in Wistar male rats by introduction of carbon tetrachloride and after they studied liver damage indicators (weight and morphology of the organ, biochemical tests, lipid peroxidation level) in the course of enteral intake of Kamchatka Bilberry syrup. Results. Introduction of Kamchatka Bilberry syrup normalized relative liver weight and transaminase activity in blood serum, attenuated cholestasis, improved the organ histological characteristics in rats with toxic hepatitis. Conclusions. The experimental results show a decrease in the intensity of free radical oxidation, reduction of cytolysis and inflammatory changes in the liver during administration of the phytodrug studied that justifies the use of Vaccinium praestans syrup as a preventive or auxiliary medicine for liver diseases treatment.

Natural muds have therapeutic effect on the human body that makes them to be a promising raw material for the cosmetics production. Methods. The research work covers physico-chemical characteristics, toxicological and microbiological properties of lacustrine-spring mud from the depths of the lake “Utinoe” in Kamchatka Territory. The irritant action of the mud has been studied in the experiment on guinea pigs. Results. Physico-chemical, mineral, microbiological and toxicological properties of the mud samples meet the standards for perfumes and cosmetics. No signs of irritation of the skin as well as mucous membranes caused by mud applications have been registered. Conclusions. Considering the data obtained, for the cosmetics production it is necessary to prepare the mud from the depths of the lake “Utinoe” by refining it through a sieve No. 05 and diluting to the right consistency. The authors developed the following types of cosmetic forms: bottles with dried mud and mineral water, tubes with liquid cosmetic mud, cosmetic mud masks, sprays and bottles with mineral water.

One of the promising neuroprotective agents are drugs of polyunsaturated fatty acids, including docosahexaenoic acid (DHA) which has a proven ability to be metabolized into compounds that regulate inflammation and restore structural and metabolic integrity of nerve tissue after injury. Methods. Using male rats with the weight of about 250 g the researchers simulated spinal cord injury and then visually monitored the locomotor activity according to vegetative function restorability scale (VVV scale). Part of the test animals have been injected DHA emulsion (subdermally in a dose of 45 mg/kg) for 3 weeks. After 5 weeks the scholars took the animals out of the experience and performed a morphological study of the spinal cord. Results. Hind limb locomotor activity after taking DHA recovered significantly better. Restoration of vegetative functions was observed at the average on the ninth day after injury. Morphological state of post-traumatic defect zone and adjacent areas indicated that the recovery of functions in the animals treated with DHA could be defined by the drug ability to modulate post-traumatic degenerative and regenerative processes. Conclusions. The experimental results indicate that the use of DHA contributes to the development of a number of metabolic and cellular processes that lead to better recovery of motor function in the animals with spinal cord injury.

The current treatment of diffuse peritonitis comprises surgical release of the source of infection and abdomen sanitization with a targeted antibacterial therapy. One of the promising concepts here is the direct endolymphatic administration of medicines which allows to make higher concentrations of the drug in the regional blood flow. Methods. The study included 48 women aged 18-65 years with diffuse purulent peritonitis. The patients were divided into three groups: 1) 18 patients who postoperatively received standard antibacterial therapy; 2) 14 patients who, in addition to standard therapy, got polyoxidonium and selenase; 3) 16 patients with clinical systemic inflammatory response without organ dysfunction who additionally were treated with endolymphatic administration of merenome, selenase and pentoglobin. Results. The peritonitis was complicated with cellular immunity depression with abnormality in the phagocytic activity of neutrophilic granules and an imbalance of pro-and anti-inflammatory cytokines, especially manifested in representatives of the third group. Using polyoxidonium and selenase caused a decrease in proinflam-matory cytokines concentrations in blood plasma.Endolymphatic drug therapy also has normalized the content of the complement system components in blood, and increase the concentration of interleukin-10, having anti-inflammatory activity. The concentration of cytokines and complement system components during vaginal-cervical secretions after endolymphatic therapy decreased greater than after traditional drug treatment. Conclusions. Endolymphatic drug therapy with the injection of antibiotics, selenase and pentoglobin helps to reduce rapidly the extent of intoxication as well as eliminate the inflammation signs in patients with the diffuse peritonitis. Immunomodulatory therapy has a positive effect on the immune status due to the effect on the lymphatic system at the regional and systemic levels.

Modern clinical course of sexually transmitted infections (STIs) is characterized by a predominance of latent forms, which play an important role in the transmission of pathogens with the subsequent development of inflammatory diseases in the pelvic organs and severe complications in young adults. Methods. The objects for the study are health status, life-style characteristics and medical care assurance of 485 sexually transmitted infection patients aged 18-29 (control - 415 healthy persons of the respective age) living in the Republic of Sakha (Yakutia). Results. The incidence of sexually transmitted infection patients of the younger age has been influenced by adverse socio-hygienic factors. The main percentage of STI was taken by trichomoniasis (40.1 %), almost one in four cases was gonorrhea (up to 24.1 %), the third place belonged to syphilis (up to 18.5 %), the fourth - to chlamydia (up to 10.9 % ). Much less frequently diagnosed - the anogenital warts (4.1 %) and urogenital herpes (2.3 %). Ceftriaxone has become the drug of choice in the basic treatment of sexually transmitted infections. Conclusions. Medico-social rehabilitation of sexually transmitted infection patients should be based on complex of medical, social and psychological steps. At the heart of patients’ social rehabilitation is introduction of healthy lifestyle elements, which is currently the most relevant and effective in a number of crucial preventive measures that should be actively used for the sexually transmitted infection patients for correcting, improving and restoring their health.

One of the hepatosis prevention ways under the effect of nitrogen oxides is the use of herbal preparations containing complexes of bioactive polyphenols having the ability to quench free radical reactions. Methods. The paper studies the preventive action of amthizol and Eleutherococcus under nitrogen oxides intoxication in Wistar rats. Results. Effect of nitrogen oxides has been accompanied by disturbances in the xenobiotics detoxification system in the liver, development of tissue hypoxia and fatty hepatosis as well as deterioration in liver esterifying function. Preliminary introduction of amtizol antihypoxant helped to reduce the injury in liver functional systems. Combined use of Eleutherococcus and amtizol showed greater protective effect for antitoxic function and lipidic metabolism. Conclusions. Use of Eleutherococcus in combination with anti-hypoxants is able to solve the problem of survival in the areas of possible man-made disasters and environmentally adverse regions.

Health care reform in Russia is mostly under the control of the bureaucratic model, through the implementation of standards. Thus, according to Art. 79 of the Federal Law of 2011.11.21 No. 323-FL «About the bases of public health protection in the Russian Federation», implementation of medical activities in accordance with the standards is mandatory. Methods. The article includes anonymous survey by 539 doctors working in medical organizations of the Primorsky Territory, where the federal standards are being introduced for antibacterial therapy. Results. Only 48.1±2.2 % of the respondents have given a positive assessment to the federal standards. In favor of improving them there were 42.3±2.1 % of doctors. Conclusions. The most important constituents of quality assurance system for using antimicrobials are: the availability of regional clinical guidelines or algorithms for antibacterial therapy; availability of clinical pharmacology service with administrative powers; availability of holistic regulatory framework aimed towards rationalization of the use of antibacterial medicines.

The article is dedicated to the economic and legal aspects of the Russian model of compulsory health insurance. It provides the analysis of the economic and legal status of the participants in the system, considers their relations regulation problems at the present stage. It also shows the urgency of the improvement and development of institutions of compulsory health insurance in order to balance the participants’ interests in the system, as well as stresses the necessity to develop competitive mechanisms.

Photodynamic therapy is a promising method for the treatment of tumors with a broad potential of clinical and research applications. The possibility to combine the diagnostic and therapeutic options is of particular note that can significantly improve treatment efficiency. However, it is important to consider carefully the issues of service organization for the photodynamic therapy. Specialists’ inadequate education, incomplete service ensuring with medical and diagnostic equipment and non-compliance of treatment protocols can lead to a significant deterioration in the results and discredit the method.

The paper provides clinical description of Ehlers-Danlos syndrome in a boy of 6 years. Based on the clinical and laboratory characteristics, a classic type of the disease with autosomal dominant inheritance has been diagnosed. This case represents a severe manifestation of connective tissue dysplasia, which requires a symptomatic treatment, including hemostatic therapy.

Absorptive optical spectra of Silybum marianum fruits tincture and silybine flavolignan solution in ethanol (40 %) have been recorded by digital spectrophotometer UV-2051PC (Shimadzu). For normalized spectra the researchers measured highs, lows, points of inflection, jaggies, the width of the absorption bands and the area, asymmetry coefficients. The content of flavolignans in Silybum marianum fruits has been evaluated by comparing the spectral parameters and the specific absorption for the tincture and silybine solution. Results. The absorption spectra of Silybum marianum fruits tincture and silybine solution were almost identical according to many spectral parameters. Conclusions. The content found in flavolignans comes to 2-4 mg/g (as silybine) with an accuracy of 2.8 % in the Silybum marianum fruits and the waves lengths of the absorption maxima are consistent with the literature data. Relatively simple, little laborious and enough accurate pectrophotometric method may well be used for determining the flavolignans in Silybum marianum fruits.

Object of this study was developing a method of standardization of low-molecular pectins-oligouronids according to the chain-length distribution for subsequent validation. Methods. Standardization of oligouronids was carried out using exclusion chromatography techniques and analysis of reducing end groups. The authors studied the eluent influence on the separation of oligouronids with molecular weights of 2.8-15.5 kDa on column with hydrophilic sorbent Shodex Asahipak GS-320 7E. Results. It has been established that the optimal separation of oligouronids on molecular weight is achieved in 0.1M of sodium nitrate at 35 °C and the eluent speed of 0.8 ml/min. The values of mass average and number average for oligouronids molecular weights obtained respectively with the exclusion chromatography methods and analysis of the end groups were similar that indicates a relatively small value of polydisperse samples and the validity of these methods for standardizing oligouronids. Conclusions. When comparing the modified tetrazolium method and Nelson method for analyzing oligouronids end groups it was determined that Nelson method allows to obtain more accurate and reliable results and it is applicable for oligouronids standardization.

Brown algae polysaccharides - are the alginates widely used in food and pharmaceutical industries as health promoting medicines in case of poisoning with heavy metals salts and radionuclides. A significant shortcoming of the alginates is their poor solubility. The purpose of research is development of a method enhancing the sodium alginate solubility based on a transferring the part of uronic acids residues in the alginate molecule to the calcium salts form. Methods. The article covers the influence of calcium content on the alginate solubility. The researchers formed sorption isotherm of calcium ions by sodium alginate in the environment of 50 % ethanol and obtained the alginate samples containing from 0.2 to 6.82 % of calcium. Also they studied the hydrogels properties of the obtained samples of calcium alginate. Results. It was found that in the case of calcium content in the alginate less than 4.44 % a partial dissolution of the alginate gel starts, while calcium content less than 0.8 % promotes a complete dissolution. There have been also an estimation of dissolution rate for various alginate samples. Calcium alginate samples containing 0.2-0.8 % of calcium showed a higher rate of dissolution by 6.2-13.4 times than the original sodium alginate. Conclusions. Technology for producing incomplete calcium salts of alginates may be a new and very efficient approach to the problem of their solubility and, therefore, improvement of consumer properties.