Represented the literature review dedicated to the problems related to the sense of vision in patients after the phacoemulsification with intraocular lens implantation. Given a detailed analysis of the causes of negative dysphotopsia, methods and technology of diagnosis, and prediction of their occurrence. Considered the ways of problems solutions related to the occurrence of negative dysphotopsia in post-operative period, trends in prevention and treatment development.

Conducted a theoretical analysis of the activities of employees of the Federal Service for Supervision of Consumer Rights Protection and Human Health. The specifics of the labor process and the main time costs for performing various kinds of work are determined. The basis of the activities of workers of Federal Service for Supervision of Consumer Rights Protection and Human Health is the interaction of the "human-person" type and the work with computer equipment for the documentation. The main stress factors are revealed and their features are described within the framework that directly follow from the main types of work. Given the features of the syndrome of professional burnout and its further consequences.

Objective. The objective of this study is the analysis of the effect of the laser radiation energy parameters with the waves of 0.81 and 1.06 μm and pigmentation levels on the depth and volume of the tumor destruction. Methods. The depth and the diameter of a destruction zoneunder the influence of the laser radiation 1, 1.5, and 3 W with the exposition of 45 and 60 sec. were assessed under pathomorphological analysis on the pigmented, lightly pigmented and non-pigmented samples of a tumor. Results. The destruction depth of the lightly pigmented and pigmented tissue with the wave of 0.81 μm is no more than 4 and 3 mm, and with the wave of 1.06 - no more than 8 and 5 mm, respectively. The destruction depth of the lightly pigmented and non-pigmented tissue under the influence of the laser radiation with the wave of 0.81 and 1.06 μm has the similar features. Conclusions. With the rise of the wave-length of the laser radiation from 0.81 to 1.06 μm, its absorption increases, and the reliance of absorption level on the pigmentation decreases.

Objective. The objective of the study is to analyze the effect of various types of antibacterial prophylaxis (local and systemic) on the severity of postoperative reactive inflammation in the early period after phacoemulsification. Methods. 185 patients - 246 eyes with age-related cataract - divided into two equal groups. Representatives of the 1^st group (123 eyes) received instillations of levofloxacin within 3 days before the operation, representatives of the 2^nd group (123 eyes) additionally - levofloxacin inside 500 mg once a day, starting the day before the intervention, for five days. The signs of reactive inflammation were evaluated according to the S.N. Fedorov and E.V. Yegorova classification at the 1, 3 and 10 days after the operation. Results. On the 1^st and 3^rd day after the surgery, significantly better results on the response from the moisture of the anterior chamber of the eye were noted among the patients of the 2^nd group. On the 10^th day, there were no significant differences between the groups. Conclusions. We can talk about a significant decrease in the severity of the reactive inflammatory process from the anterior chamber of the eye after phacoemulsification with systemic antibacterial prophylaxis with fluoroquinolones.

Objective. The purpose of this study was to determine the fecal level of zonulin, tumor necrosis factor alpha (TNFa) and nitric oxide metabolites in children with gastrointestinal forms of food allergy (FA) and to assess their pathogenetic significance in the diagnosis of IgE-dependent and IgE-independent FA. Methods. It was clinical and laboratory examines 39 children with food allergy to the cow milk protein at the age of 6 months to 3 years (Group I). The comparison group (Group II) consisted of 30 healthy children. The content of zonulin was determined using Immunodiagnostic (Germany) reagents using enzyme-linked immunosorbent assay (ELISA). Immunological study of fecal TNFa was performed with the help of BSM (USA) reagents using the enzyme-linked immunosorbent assay (ELISA) method. The concentration of NO metabolites in co-filters was determined using an enzyme immunoassay (ELISA) and the "Total Nitric Oxide and Nitrate/Nitrite Parameter Assay Kit" (R&D Systems, USA). Results. Mean concentrations of zonulin in fecal samples in FA children and in control group children were 1.79±0.16 and 0.75±0.01 ng/ml, respectively (p<0.05). The level of TNFa (31,04±2,71 mmol/L) in FA children was in 7.6 times higher than in the control group. Analyze of the NO metabolites content in children with IgE-dependent and IgE-independent FA show the multidirectional changes in production of nitric oxide in children of different subgroups. Conclusions. Determination of fecal zonuline concentrations, TNFa and NO metabolites is an informative criterion for damage of the intestinal barrier in the development of food allergies in children. High numbers of these fecal markers are characteristic of the IgE-dependent form of the disease, increased zonulin, TNFa and decreased NO metabolites are characteristic of IgE-independent FA in children.

Objective. An attempt has been made to analyze the level and structure of the incidence of the main forms of tumor of the organ of vision in Primorskiy territory in 2011-2016 based on the materials of Primorsky Center for Eye Microsurgery, LLC. During this period, 1256 patients aged 4 to 86 years old applied to PCEM with eye tumors. Methods. Ophthalmic and general methods of instrumental diagnostics were used: ultrasonic morphometry, optical coherence tomography, angiography, color Doppler mapping, magnetic resonance imaging, positron emission tomography, histological and immunohistochemical studies. Results. Neoplasms of the eyelids were the most common cause of the treatment - 87 %. Neoplasms of the surface of the eyeball and intraocular localization were registered in 5.7 % of cases. 37 patients of them suffered from metaplastic conjunctival processes, and intraocular neoplasms were first detected in 35 patients. Primary neoplasms of the orbit are diagnosed in 16, secondary -in 4, metastatic processes of the eye and orbit - in 3 cases. More than 90 % efficiency of surgical treatment of organ tumor of the eye is noted at the time of dispensary observation up to 5 years. Only 3.3 % of patients needed combined and high-tech non-invasive treatment and lifelong dispensary supervision. Conclusions. To improve the quality of medical services for the population, it is necessary to improve the reporting protocols for oncologic ophthalmic diseases. Regional branches of Ophthalmological Association of Russia as the primary care of specialized areas of medicine.

Objective. The objective of the study is to analyze the bioelectrical activity of the brain in the early stages of age-related macular degeneration. Methods. We studied the deviations in the bioelectrical activity of the brain in the early stages of age-related macular degeneration of the retina in 10 patients aged 60-77 (control - 10 practically healthy people). The analysis was performed with the help of the RS MEGI-01 developed in the laboratory of environmental neurocybernetics of the Research Center 'Arktika' FEB RAS. The obtained data were subjected to a software-hardware analysis and represented in the form of a spectral matrix and spectrum envelope graphs displaying the spectral estimation in different frequency ranges corresponding to a certain group of vegetative receptors. Results. In patients with macular degeneration of the retina detected the regularities in the characteristics of the spectral matrix on qualitative and quantitative characteristics. For the pathological state were received the spectral estimates for the sum of the spectral matrices. Significant differences in the frequency ranges reflecting the state of the vegetative receptors of the eye were revealed. Conclusions. Objectively confirmed data from clinical trials have proved the advisability of using diagnostics by studying the bioelectrical activity of the brain in patients with age-related macular degeneration. Criteria for screening diagnostics of this disease have been developed with the help of examination on the RS-MEGI-01

Methods. The clinical efficacy of the prostaglandin analogue without preservative - eye drops "Taflotan" (tufluprost 0.0015 %) was studied in the protocol of treatment of 34 patients 47-80 years old with POAG I-III st. The observation period is 6 months. Results. Taflotan demonstrated a sufficient hypotensive effect: from 19.9 % in the far-advanced to 23.8 % in the initial stages of the disease, 94.1 % of patients were well tolerated without causing general and local negative reactions. Conclusions. To preserve visual functions, stabilize the glaucoma process and tear production in the initial stages, tuflotan should be used as an independent drug, and in the far-reaching stage of POAG in combination with a2-adrenomimetic (brimonidine).

Objective. The objective of the study is to search for immunological predictors of the rate of progression of glaucoma optic neuropathy reflecting the state of the extracellular matrix. Methods. In 75 patients with primary open-angle glaucoma (POAG) of stages I-IV in the tear fluid were determined the content of matrix metalloproteinases (MMPs) 8 and 9 and their tissue inhibitor (TIMP-1). The observation period is 1 year. Results. MMP-9 and MMP-8 levels and their ratio with TIMP-1 significantly increased with a rapid progression of POAG. The ratio of mMp-9 / TIMP-1 with rapid disease progression was 2.5 3 times higher than with slow progression and 3.5 times higher than with stabilized POAG. Conclusions. The role of the MMPs system and their relationship to tissue inhibitors in the pathogenesis of POAG is confirmed. The data obtained will make it possible to recommend a study of the performance of the extracellular matrix for the detection of the risk of rapid progression of glaucoma optic neuropathy and the connection of more active therapy.

Objective. The structure, prevalence and localization of diseases of the oral mucosa in a population older than working age in a socially-organized team were studied. Methods. A continuous dental examination was conducted, according to the recommendations of experts from WHO (1997), elderly and older persons who were permanently residing in the social service institution of Khabarovsk. Results. Diseases of the oral mucosa, including associated pathology, were diagnosed in 47.5 % of the examined and 2.4 more common in women than in men. The stomatitis of various genesis (18.8 % of observations), leukoplakia (13.1 % of observations), candidiasis (15.6 % of observations), red flat lichen (0.8 % of observations) were diagnosed. 'Other diseases' (fibromatosis, hemangioma, erythroplasty) were found in 12.3 % of patients. Conclusions. Proceeding from the needs of the examined society in preserving the quality of life and functioning of the dentoalveolar system, we consider it expedient to form a holistic approach that includes measures for improvement and educational propaganda, as well as regular screening and timely treatment of general and dental diseases, taking into account the age-sex mucological characteristics of dental status.

Objective. Despite the efforts aimed on HIV-infection control on the territory of Russian Federation the epidemiologic situation is deteriorating. The goal of the research was to analyze main indices concerning HIV-infection epidemiologic process on the territory of Russian Far East during last 10 years (2006-2015). Methods. The research was based on analysis of the official statistical data received from the territorial and federal agencies of the Russian Federation. Results. During the last five years (2011-2015) was detected an increase in HIV prevalence and incidence rates in 1.5 and 1.7 times respectively. The impact of sexual transmission route is increasing. However, the parenteral route of transmission is still prevailing. The percentage of patients of 40 years and older is increasing. Simultaneously, the ratio of newborns and teenagers is declining. The rate of viral hepatitis B among HIV-infected patients has increased from 2.9 to 3.5 %. Prevalence rate of viral hepatitis C is persistently high - 32.3 %. Conclusions. Obtained results indicate on the necessity of active prophylactic measures directed on prevention of the spread of HIV-infection and viral hepatitis B and C on the territory of the Russian Far East.

Objective. Treatment and prevention of postoperative complications in patients with purulent-septic pathology remain one of the most urgent problems of modern surgery. One of the groups of drugs that are used as an adjuvant therapy for surgical sepsis are intravenous immunoglobulins (IVIG). Methods. We observed 56 patients with sepsis, which were divided into 3 groups. 1^st group (25 patients) received traditional treatment, 2^nd group (14 patients) received standard IVIG (Ig G) in addition to traditional therapy, 3^rd group (17 patients) in addition to conventional therapy received enriched IVIG (Ig M+Ig A). Results. Comparative assessment of the combination of intravenous immunoglobulin's and traditional therapy indicated the clinical effectiveness of IVIG therapy, which results in reducing the severity of systemic inflammation, the severity of the disease and the mortality in patients with surgical sepsis. Conclusion. Thus, after analyzing the results obtained, it was shown that it is advisable to include IVIG in complex therapy of patients with surgical sepsis.

Objective. To estimate the prevalence of the classical and additional cardiovascular risk factors in the men of young and middle age. Methods. In the Department of the Hospital Therapy MMA have been inspected 203 men at the age 39.5±7.0 of years. Have been evaluated the complaints, the presence and the duration of arterial hypertension, hereditary anamnesis, carbohydrate and lipid metabolism, have been carried out ultrasound heart, carotid arteries, internal organs examinations. The patients with the defeat of the target organs and the associated clinical states were not included in a study. Results. Have been formed two groups: 1^st - 69 men at the age 41.4±6.2 of years with subclinical atherosclerosis; 2^nd the group -134 men 38.2±7.4 of years with the intact endothelial pavement. In those investigated 1^st group more frequently were revealed burdened heredity on the cardiovascular diseases and diabetes mellitus 2 type, alimentary obesity. The manifestation of arterial hypertension and duration differed with subclinical atherosclerosis with it's comparable frequency. There were more characteristic dyslipidemia for the patients from 1^st group due to the LDL-fraction, the higher frequency of the development of prediabetes. During an ultrasound heart examination in all patients has been noted normal geometry and mass of left ventricle; however, in 1^st group has already been determined the initial signs of left atrium remodeling. In men with subclinical atherosclerosis also more frequently have been verified early stage of nonalcoholic steatohepatosis. Conclusions. Summing up the sums, it should be noted that each third man-soldier after 30 years when the concealed disturbances of lipid and carbohydrate metabolism are present, is situated in the zone of the potential risk of the development of subclinical atherosclerosis. The revealed changes in the liver and the dysfunction of the pancreas can be examined as the additional factors of the risk of early atherosclerotic changes.

Objective. Studied kidney functiona and urinary syndrome after using Diclofenac and Celecoxib in patients with oxalate nephropathy with primary gonarthrosis. Methods. We examined 51 women 45-60 years old, who suffered from oxalate nephropathy for more than 20 years with chronic kidney disease 1-2 stage with a glomerular filtration rate (GFR) of not less than 60 ml/min. Patients of the 1^st group (22 people) took diclofenac sodium (course dose of 3000 mg) for a month, patients of the 2^nd group (29 people) took celecoxib (course dose 6000 mg). Assessed GFR in dynamics, uric acid clearance and urinary syndrome (before treatment, on the 30^th day of treatment, and a month after the drugs dechallenge). Results. By the 30^th day of treatment with diclofenac, nephrotoxic effects were observed, characterized by a statistically significant decrease in GFR (from 89.0±9.1 to 57.5±2.9 ml/min) and uric acid clearance (from 5.2±9.1 to 4.1±0.4 ml/min). Microscopy of urine sediment showed an increase in aggregation of calcium oxalates, the appearance of microhematuria and proteinuria. Celecoxib by this time led to a moderate decrease in GFR (from 85.5±8.2 to 61.2±9.3 ml/min), but did not cause changes in the clearance of uric acid and urinary sediment. A month after the drugs dechallenge, all the indicators returned to their original level. Conclusions. Celecoxib demonstrated less nephrotoxicity than diclofenac. The latter caused an exacerbation of nephropathy, an increase in oxalate-calcium crystalluria, the appearance of microhematuria and proteinuria. Celecoxib only reduced the rate of glomerular filtration, without causing changes in urinary sediment.

Objective. Comparison of the measurements results of the eye parameters were conducted on the following instruments Lenstar LS900, IOLMaster, Pentacam HR and OPD-Scan II. Methods. The study involved 50 patients (54 eyes). For the purpose of calculating the optical power of the intraocular lens, biometry was performed on these instruments with statistical processing of the obtained data. Results. When measuring the anteroposterior axis and the depth of the anterior chamber of the eye, no clinically and statistically significant difference was obtained by all instruments. A statistically significant difference was found when comparing keratometry on the Lenstar LS900 biometer and Pentacam HR and OPD-Scan II keratotopographs. Conclusios. Between the main parameters of the eye, determined with the Lenstar LS900 and IOLMaster, there is a high dependence and repeatability of the results. The depth of the anterior chamber of the eye, measured with instruments of different types, in formulas for calculating the optical strength of intraocular lenses (Haigis, Holladay, Barret, Olsen) can be used to obtain new calculation algorithms. The keratometric data on Pentacam HR in the pupillary and 3 mm pupil zones and on OPD-Scan II in combination with the results obtained with the Lenstar LS900 and IOLMaster, because of significant differences, may be useful for identifying more accurate variants of intraocular lenses.

Objective. Study of vascular response to psychoemotional stress in young women with idiopathic arterial hypotension. Methods. Two groups of women aged 18-22 years were examined. Test group - 16 women with idiopathic arterial hypotension and control group - 10 women with normal arterial pressure. Psychoemotional exercise was performed according to E. Kraepelin. Ultrasound dopplerography of the vessels was performed at rest and after exercise. Results. With hypotension, stress provoked a decrease in the final diastolic blood flow velocity in the vertebral artery and a decrease in the diameter of the posterior tibial artery. Conclusions. With hypotension, psychoemotional load is accompanied by a minimal reaction of the arteries and veins, which is a manifestation of insufficient adaptation, and is caused by low vascular tone, acceleration of arterial and slowing of venous blood flow.

Objective. In recent years, the frequency of occurrence of Enterococcus faecalis as an etiological factor of infection of the urinary system has increased, according to different authors, up to 14.216 %. It has been established that enterococci synthesize a large number of virulence factors that contribute to the development of the infectious process. Methods. 57 cultures of E. faecalis isolated from the urine of children with a urinary tract pathology were studied, the cases were analyzed. Results. Cultures of enterococci showed a phenotypic heterogeneity of biological properties, including virulence factors. It was established that the intoxication syndrome prevailing in the clinical picture is caused by a complex of pathogenic factors of fecal enterococcus causing toxic tissue damage. Conclusions. A correlation between the degree of adhesion, hemolytic, gelatinase and lecithinase activity was revealed with symptoms associated with upper urinary tract damage, which indicates the importance of microbial adhesion and certain pathogenicity factors of E. faecalis in the pathogenesis of the infectious inflammatory process.

Objective. Theobjective of the study is to evaluate the clinical efficacy of the own modified myoplasty method in correcting strabismus. Methods. The material of 86 observations made a comparative evaluation of the results of strabismus treatment according to the author's method (patent of the Russian Federation No. 2423068) and the traditional method (according to Avetisov-Makhkamova). Results. After the first stage of surgical treatment, a decrease in the deviation angle to 0-5° was achieved in 85.3 % of observations with modified myoplasty and in 46.7 % of cases with the traditional method of surgical treatment of strabismus. Conclusions. In all cases, modified myoplasty allowed to reduce the number of operated extraocular muscles, which reduced the traumaticity and the number of stages of surgical correction of strabismus with large angles of deviation.

Objective. The study objective is the development of methods for the quantitative analysis of a new nootropic composition containing Phenotropil and Gammalone. Methods. For quantitative determination of Phenotropil, ultraviolet spectrophotometry was used, for Gammalone titration was used. Results. The relationship between the optical density of the solution and the content of Phenotropil in it, the volume of the titrant and the hinge of the Gammalone was linear in the Phenotropil content and in the range from 0.01 to 0.1 %, and of the Gammalone from 0.1 to 0.5 g. Conclusions. The results of the validation evaluation of the quantitative determination of Gammalone and Phenotropil and the model mixture showed that these techniques allow reliable determination of the starting substances in their joint presence.

To assess the role of photobiomicroscopy in everyday clinical practice, an analysis was made of the diagnosis of diseases most common in the practice of an ophthalmologist. Photo-biomicroscopy was provided to patients suffering from glaucoma, inflammatory and dystrophic eye diseases, oncological pathology and strabismus. In each group, according to the purpose of dynamic observation, universal photo registration parameters were used for objective comparative observation and further processing of photobiocroscopic images using computer software. It is shown that photobiomicroscopy meets the principles of personalized objective assessment of the course and effectiveness of treatment of eye diseases, image processing of a personalized archive, has great potential for clinical analysis, scientific research, as well as in groups of diseases, operations and therapy.

Retried the experience of the study conducted at the Memorial Sloan Kettering Cancer Center (USA) and devoted to the validation of ABC systems - a new classification of kidney tumors, based on relations between neoplasms and vascular system of the organ. In order to improve the vessels imaging, 39 patients underwent a contrast-enhanced computed tomography according to a special protocol before laparoscopic resection of the kidney. Statistical analysis revealed a strong connection between the stage of neoplasm according to the new classification, the time of ischemia and the volume of intraoperative blood loss. Thus, the ABC scale has shown significant opportunities in predicting the complexity of surgical intervention.

Objective. Conducted the analysis of the ultrasound diagnostics of the destructive acute appendicitis within the framework of a Centre. Methods. Examined 394 patients aged 18-87 admitted to the clinic with suspected acute appendicitis. Sonography was performed by one specialist on Phillips EnVisor HD and GE Logiq 400 devices. In 147 cases, destructive acute appendicitis was diagnosed; in 247 people this diagnosis was excluded. Results. The appendix with destructive acute appendicitis was visualized in 79 %, without it - in 28.9 % of cases. The sensitivity of the method was 83.8 %, the specificity was 95 %, the predictive value of the positive result was 79 %, the predictive value of the negative result was 95.1 %, the accuracy was 88.7 %. Conclusions. Ultrasound diagnosis of acute appendicitis is informative, easy to learn method. To diagnose destructive acute appendicitis, the following are most informative features: "target", incompatibility of the process, an increase in its diameter of more than 7 mm, the presence of coprolites, and a thickening of the periapendicular filament.

Objective. The study objective is a clinical analysis of the effectiveness of anxiolysis in ophthalmic surgery. Methods. A retrospective analysis of 9949 anesthetic tools for ophthalmic interventions on the basis of PTSG in 2014-2016. Anxiolysis and controlled anesthesia were carried out in 9319 cases, 415 combined anesthesia using the laryngeal mask, 205 anesthetics with endotracheal intubation, and in 10 anaesthesia with facial masks. Results. Psychomotor agitation was most often observed in the group of patients who received a combination of 'fenozepam plus fentanyl' (3.4 %) during the operation, arterial hypotension during the intervention, as well as in the early and late postoperative periods, was more often diagnosed in the same patients (2 %) , Subjective negative feelings were registered among individuals who received combinations of 'droperidol plus fentanyl' (7.1 %) and 'fenozepam plus fentanyl' (4.7 %), cardiac rhythm disturbances prevailed in the group 'droperidol plus fentanyl' (0.6 %). Conclusions. The analysis of practical work made it necessary to abandon the use of combinations of 'phenazepam plus fentanyl' and 'droperidol plus fentanyl' due to the high frequency of adverse reactions occurring during and after the operation. Among the benzodiazepines, midazolam was preferred, as this drug has a quick onset of action, is more 'manageable', and demonstrates a good anxiolytic effect with fewer adverse reactions and, what is very important, stabilizes the hemodynamics.

The description of the early sternomediastinitis after the bypass surgery oin the patient aged 69 years old. Complication was the reason for using an open method of management with negative pressure therapy in combination with antibacterial treatment. A foam sponge was used as an absorbent material. A negative pressure of -70 mm Hg was created by using an aspirator. The bandage was changed every 3-4 days. A rapid growth of granulating tissue, a significant reduction in the wound surface, and an improvement in the patient>s emotional state were noted. Dismissed from the hospital in a satisfactory condition on the 14^th day after the beginning of the use of vacuum suction drainage system. The application of skin seams was not required due to complete wound closure with granulations with the formation of a full scab of the anterior thoracic wall.

Objective. For the purpose of development and deployment of well-timed preventive and improving actions, prediction and management of health of the children's population, including, in system of social and hygienic monitoring, the systemic research of indexes of development of children in specific conditions of the habitat, as at the individual, and population level is necessary. Methods. The research of criteria of a biological age of children of 3-11 years living in Vladivostok is conducted. Identification of relationships of cause and effect in system habitat factors - biological development of children is carried out. The complex of priority actions for prophylaxis of violations of health of the children's population is evidence-based and developed. Results. It has been established that the modern preschool children and younger students in Vladivostok in most age and sex groups outperform their peers on the previous decades the average for length and weight. The early secondary dentition at children is revealed. The maximal impact on indicators of biological development of children is made: nutriyentny structure of food allowances of the child (19,9-52,3 %), the hygienic normalized factors of a way of life (14,3-48,9 %), and also social and hygienic living conditions (20,8-33,2 %). On the eruption of permanent teeth, in addition to the above factors affect women's nutrition during pregnancy (12,9-21,0 °%). Conclusions. Scientifically substantiated and developed a set of priority actions for the prevention of regional children's health problems, which is proposed to be used in the implementation of the regional model of social and hygienic monitoring of children's health.

Conducted the assessment of the activity, the main results of the work, as well as the personnel potential of the clinic Primorsky Center of Eye Microsurgery, LLC, taking part in the provision of specialized ophthalmic care for patients in the Far Eastern Federal District - from the beginning of activity until 2016. The therapeutic and diagnostic capabilities of the center are evaluated, which made it possible to withdraw the provision of ophthalmic care to the population at the modern level. The number and structure of ophthalmological operations and treatment courses in the clinic under various socially significant eye diseases are analyzed.

Objective. The study objective is to analyze the relation between psychophysiological adaptive responses and military students' personality of Ministry of Emergency Situations University at training conditions. Methods. The selection is formed from 49 military students of Ministry of Emergency Situations of Russia aged 19-21years old. A multifactorial personality questionnaire "Adaptability" and correction tables (Landolta rings) were used. We studied the parameters of the electrocardiogram tracing. The condition of central nervous system was assessed following visual motor reaction. Results. Detected the differences in separate parameters of the cardiac rate after the smoke and heat training facility in persons with different levels of adaptive abilities. In military students with satisfactory adaptation the average value was higher than in the group with high adaptive abilities. Discovered the interrelation between psychophysiological responses and human personality. Personal adaptive potential and its elements (behavioral control and ethical standards) related to the frequency and the variability of the heart rate, speed parameters, and concentration capacity and accuracy. The scales typifying accentuation of personality traits correlate to the frequency and the variability of heart rate, the Baevskiy tension index, vegetal balance index, functional status level, concentration functions, response persistence, index of subcortical centers activation, reaction mean time and speed response level. Conclusions. The study of the relations between psychophysiological adaptive responses and military students' personality at training conditions widen the concept of professionally important psychological features of professionals related to emergency situations.

A modern system of medical education is considered, which presupposes training with a high level of independence with the leading role of the trainee's personality. At the same time, the organization of classroom and extracurricular independent work requires serious teaching and methodological support, application of the natural anatomical preparations obtained with the use of modern technologies and interactive forms of conducting classes in the educational process.

A clinical observation of a combination of two severe pathological processes, the through macular opening and postthrombotic macular edema of the retina in a 65-year-old man, is described. Combined approach to treatment - intravitreal administration of aflibercept with subsequent transconjunctival vitrectomy - allowed closing the anatomical defect in the foveolar zone with increased visual acuity and restoration of reading ability.