No 2 (2010)
5-9 265
Abstract
Marine animals and plants are source of nature-occurring
compounds varied by chemical structure and biological
activity. These are secondary metabolites. Many of these substances
and their synthetic analogues exhibit pharmaceutical
properties and may serve as a basis to develop new pharmaceutical
substances and drugs. The paper overviews marine objects
and derived compounds, pharmaceutical effects, and field of
their application in medicine.
compounds varied by chemical structure and biological
activity. These are secondary metabolites. Many of these substances
and their synthetic analogues exhibit pharmaceutical
properties and may serve as a basis to develop new pharmaceutical
substances and drugs. The paper overviews marine objects
and derived compounds, pharmaceutical effects, and field of
their application in medicine.
10-15 291
Abstract
The paper describes a system destined for collecting
naturally occurring biological response modifiers to be used
in oncological practice. It is based upon estimation of their efficiency
during chemotherapeutical treatment and surgical removal
of tumors.
naturally occurring biological response modifiers to be used
in oncological practice. It is based upon estimation of their efficiency
during chemotherapeutical treatment and surgical removal
of tumors.
15-19 274
Abstract
The paper gives reliable information on both omega‑3
fatty acid preparations available on Russian market and present
situation with their use in medical practice. Information on lipid
composition of 15 preparations is given as well as data on their
main fatty acid. Present situation with scientific investigations
and medical application of omega-3 fatty acid as it looked in top
level scientific journal of the World was analyzed using Web of
Science. It was found that interest to these fatty acid increases
and area of their application is enlarged. Up to now the leading
places in the application are occupied by cardiac and vascular
diseases. Among others areas neural, psychological diseases and
oncology have increased interest to the preparations.
fatty acid preparations available on Russian market and present
situation with their use in medical practice. Information on lipid
composition of 15 preparations is given as well as data on their
main fatty acid. Present situation with scientific investigations
and medical application of omega-3 fatty acid as it looked in top
level scientific journal of the World was analyzed using Web of
Science. It was found that interest to these fatty acid increases
and area of their application is enlarged. Up to now the leading
places in the application are occupied by cardiac and vascular
diseases. Among others areas neural, psychological diseases and
oncology have increased interest to the preparations.
20-26 172
Abstract
The authors analyze properties of bio-polymer
matrix materials being partial structurally-functional analogues
of hyaluronic acid-based glycopolymers. Original modified
polysaccharidic compounds had inhibiting effect on the
capability of neutral stem cells to differentiate. To estimate
cell vitality after cultivation on the substrates under study,
the authors have re-cultivated them under the conditions of
induced adhesion and differentiation. All the studied variants
of glycopolymer matrixes have proved the capability of cells to
differentiate and regular grow under the conditions of neuroinduction
substrate that included dimerous forms of IV type
collagen. One of the materials included modified derivatives
of uronic acids has been recommended as promising matrix
capable of inhibiting undesirable spontaneous differentiation
of neutral stem cells during derivation and conservation of their
biomass needed to create artificial implants of nervous tissue.
matrix materials being partial structurally-functional analogues
of hyaluronic acid-based glycopolymers. Original modified
polysaccharidic compounds had inhibiting effect on the
capability of neutral stem cells to differentiate. To estimate
cell vitality after cultivation on the substrates under study,
the authors have re-cultivated them under the conditions of
induced adhesion and differentiation. All the studied variants
of glycopolymer matrixes have proved the capability of cells to
differentiate and regular grow under the conditions of neuroinduction
substrate that included dimerous forms of IV type
collagen. One of the materials included modified derivatives
of uronic acids has been recommended as promising matrix
capable of inhibiting undesirable spontaneous differentiation
of neutral stem cells during derivation and conservation of their
biomass needed to create artificial implants of nervous tissue.
26-31 193
Abstract
The authors present results of studies devoted to the
development of microstructured nano-heterogenous matrix materials
that ensure regulation of cell growth and differentiation
to create artificial tissue implants based upon cell bio-polymer
constructions. To create microstructured matrixes, the authors
have used original bio-polymer compounds of protein and carbohydrate
origin modified and positioned in the compound via
multiport injection spraying unit. Using neutral stem cell cultures
allows demonstrating the capability of one matrix types to
induce directed cell growth and differentiation along the composition
tracks, and of other matrix types - to inhibit differentiation
with cell congregation positioning.
development of microstructured nano-heterogenous matrix materials
that ensure regulation of cell growth and differentiation
to create artificial tissue implants based upon cell bio-polymer
constructions. To create microstructured matrixes, the authors
have used original bio-polymer compounds of protein and carbohydrate
origin modified and positioned in the compound via
multiport injection spraying unit. Using neutral stem cell cultures
allows demonstrating the capability of one matrix types to
induce directed cell growth and differentiation along the composition
tracks, and of other matrix types - to inhibit differentiation
with cell congregation positioning.
32-36 243
Abstract
Using models of passaged Ehrlich adenocarcinoma
and Lewis lung carcinoma in mice, the authors have studied
effects of pectins with various molecular mass that were orally
introduced at a dose of 50 and 100 mg/kg. The pectins with
molecular mass of up to 20 kDa induced Ehrlich adenocarcinoma
growth; the 50 mg/kg dose increased antitumor effect of
cyclophosphan. Experiments with Lewis lung carcinoma showed
that all specimens have had no effect on the growth of primary
tumor. This notwithstanding, the pectins with molecular mass
of up to 20 kDa reliably decreased the number of metastatic
focuses and considerably increased anti-metastatic effect of
cyclophosphane.
and Lewis lung carcinoma in mice, the authors have studied
effects of pectins with various molecular mass that were orally
introduced at a dose of 50 and 100 mg/kg. The pectins with
molecular mass of up to 20 kDa induced Ehrlich adenocarcinoma
growth; the 50 mg/kg dose increased antitumor effect of
cyclophosphan. Experiments with Lewis lung carcinoma showed
that all specimens have had no effect on the growth of primary
tumor. This notwithstanding, the pectins with molecular mass
of up to 20 kDa reliably decreased the number of metastatic
focuses and considerably increased anti-metastatic effect of
cyclophosphane.
36-39 306
Abstract
The paper presents study into anti-tumor and antimetastatic
effects of sulphated polysaccharide fucoidan derived
from sea brown algae Laminaria japonica using models of passaged
Ehrlich adenocarcinoma and Lewis lung carcinoma in mice.
The average molecular mass of the specimen under study was 75
kDa. Fucoidan was introduced orally at a dose of 50 and 100 mg/
kg. Fucoidan has had no effect on the growth of Ehrlich adenocarcinoma
and cyclophosphane's efficiency. At a dose of 100 mg/kg
fucoidan had inconsiderable but reliable decrease in mass of primary
tumor of Lewis lung carcinoma, and at both dosages reliably
decreased number of metastatic focuses. Given fucoidan, the antimetastatic
effect of cyclophosphane increased 1.7 to 2.5 times.
effects of sulphated polysaccharide fucoidan derived
from sea brown algae Laminaria japonica using models of passaged
Ehrlich adenocarcinoma and Lewis lung carcinoma in mice.
The average molecular mass of the specimen under study was 75
kDa. Fucoidan was introduced orally at a dose of 50 and 100 mg/
kg. Fucoidan has had no effect on the growth of Ehrlich adenocarcinoma
and cyclophosphane's efficiency. At a dose of 100 mg/kg
fucoidan had inconsiderable but reliable decrease in mass of primary
tumor of Lewis lung carcinoma, and at both dosages reliably
decreased number of metastatic focuses. Given fucoidan, the antimetastatic
effect of cyclophosphane increased 1.7 to 2.5 times.
39-42 262
Abstract
The authors have studied composition of 1-O-alkylglycerol
ethers (AGE) derived from liver lipids of Berryteuthis
magister squid and their effect on lipid metabolism, state of hepatobiliary,
anti-oxidative systems and hematological parameters of
rats in case of experimental alimentary dislipidemy. Antioxidative,
antianemic and immune-modulating effects of AGE allowed developing
a derivation method and standardizing composition of
dietary supplement. The authors recommend wide application of
AGE derived from Berryteuthis magister squid liver lipids to rehabilitate
patients in case of various pathological conditions.
ethers (AGE) derived from liver lipids of Berryteuthis
magister squid and their effect on lipid metabolism, state of hepatobiliary,
anti-oxidative systems and hematological parameters of
rats in case of experimental alimentary dislipidemy. Antioxidative,
antianemic and immune-modulating effects of AGE allowed developing
a derivation method and standardizing composition of
dietary supplement. The authors recommend wide application of
AGE derived from Berryteuthis magister squid liver lipids to rehabilitate
patients in case of various pathological conditions.
43-45 187
Abstract
To identify NO-modulating component in the spectrum
of pharmacological effects of opium analgesics, the authors
have conducted investigation into the dynamics of nitric oxide
metabolite content (nitrate/nitrite-ions) in blood serum in patients
with oncologic diseases. Irrespective of men's age and
pathology localization, one-time application of the drug as part
of pre-operative anesthesia resulted in reliable NO-inhibiting
effect. Despite of forming adequate analgesia in women, there
was an activation of nitroxidergic processes, most evident in case
of genital system pathology. The paper discusses mechanisms of
implementation and role of this phenomenon in developing personified
methods of anti-pain therapy.
of pharmacological effects of opium analgesics, the authors
have conducted investigation into the dynamics of nitric oxide
metabolite content (nitrate/nitrite-ions) in blood serum in patients
with oncologic diseases. Irrespective of men's age and
pathology localization, one-time application of the drug as part
of pre-operative anesthesia resulted in reliable NO-inhibiting
effect. Despite of forming adequate analgesia in women, there
was an activation of nitroxidergic processes, most evident in case
of genital system pathology. The paper discusses mechanisms of
implementation and role of this phenomenon in developing personified
methods of anti-pain therapy.
45-47 227
Abstract
The authors estimate efficiency of calcium alginatebased
dietary supplement using observation results of two patient
groups with various manifestations and localization of allergic
dermatitis, and consider that the dietary supplement allows normalizing
absorbing and phagocytic activity of neutrophils, decreasing
intensity and duration of skin manifestations of allergy,
and reducing recovery period.
dietary supplement using observation results of two patient
groups with various manifestations and localization of allergic
dermatitis, and consider that the dietary supplement allows normalizing
absorbing and phagocytic activity of neutrophils, decreasing
intensity and duration of skin manifestations of allergy,
and reducing recovery period.
48-50 200
Abstract
The author describes kinetics of sorption between
strontium and yttrium ions and sodium alginate and enterosorbents,
and identifies indices of maximum strontium- and
yttrium-binding activity of the sorbents under study in the pH
range of 2 to 6. The Langmuir adsorption model has been used
to characterize the isotherms and find sorption indices. The experiments
show that the sodium alginate specimen seem to be
most efficient sorbent of stable strontium and yttrium isotopes
that makes it possible to use sodium alginate as a basis for creating
high-efficiency radioprotectors.
strontium and yttrium ions and sodium alginate and enterosorbents,
and identifies indices of maximum strontium- and
yttrium-binding activity of the sorbents under study in the pH
range of 2 to 6. The Langmuir adsorption model has been used
to characterize the isotherms and find sorption indices. The experiments
show that the sodium alginate specimen seem to be
most efficient sorbent of stable strontium and yttrium isotopes
that makes it possible to use sodium alginate as a basis for creating
high-efficiency radioprotectors.
51-53 262
Abstract
The authors describe their own method of deriving
dry extracts from plant materials. Absorption optical spectrum
and chromatograms of initial products and dry extracts reliably
coincide. This procedure of preparing dry extracts can be used
during production of plant-derived medications.
dry extracts from plant materials. Absorption optical spectrum
and chromatograms of initial products and dry extracts reliably
coincide. This procedure of preparing dry extracts can be used
during production of plant-derived medications.
53-55 281
Abstract
The authors describe their own method of representing
absorption light spectra in the form of symbolic equations
that show representative spectral signs. These equations
can be used when analyzing, comparing, classifying and creating
databases of spectral characteristics of liquid extracts from
drug plants.
absorption light spectra in the form of symbolic equations
that show representative spectral signs. These equations
can be used when analyzing, comparing, classifying and creating
databases of spectral characteristics of liquid extracts from
drug plants.
56-58 236
Abstract
The authors provide data about rat experiments
aimed to study membrane-protective effect of Laminaria
japonica
brown algae-derived extract, identify physiological
characteristics of red blood cells and content of neutral lipids
and phospholipids in case of hypercholesterol diet. The
hypercholesterolemia is characterized by increasing volume
and osmotic fragility of red blood cells, ratio 'cholesterol/
phospholipids', quantity of cholesterol, sphingomyelin,
lysofractions of phosphopipids, and decreasing concentration
of cholesterol, phosphatidylinositols and phosphatidic acid
ethers. The introduction of the Laminaria japonica-derived
extract results in regulation of the aforementioned parameters.
aimed to study membrane-protective effect of Laminaria
japonica
brown algae-derived extract, identify physiological
characteristics of red blood cells and content of neutral lipids
and phospholipids in case of hypercholesterol diet. The
hypercholesterolemia is characterized by increasing volume
and osmotic fragility of red blood cells, ratio 'cholesterol/
phospholipids', quantity of cholesterol, sphingomyelin,
lysofractions of phosphopipids, and decreasing concentration
of cholesterol, phosphatidylinositols and phosphatidic acid
ethers. The introduction of the Laminaria japonica-derived
extract results in regulation of the aforementioned parameters.
59-62 192
Abstract
The authors estimate binding ability of ι-carrageenan
with respect to anti-tumor drugs - cyclophosphamide and
dacarbazine. The carrageenan selectively bind and retain molecules
of dacarbazine in the polysaccharidic gel medium structure
due to chemical adsorption processes that can be used to create
new all-inclusive drugs for recipient-oriented delivery of drug
substances with controlled release of an active compound.
with respect to anti-tumor drugs - cyclophosphamide and
dacarbazine. The carrageenan selectively bind and retain molecules
of dacarbazine in the polysaccharidic gel medium structure
due to chemical adsorption processes that can be used to create
new all-inclusive drugs for recipient-oriented delivery of drug
substances with controlled release of an active compound.
62-66 268
Abstract
The paper studies acid hydrolysis of high-etherified
and low-etherified pectins in 0.5МHCl at 90°С. The acid hydrolysis
of high-etherified pectin is characterized by decreasing
extent of etherification and production of low-etherified pectin.
In case of low-etherified pectin hydrolysis, the rate rapidly
decreases during the first 1.5 hours, and then remains almost
unchanged. The first stage includes production of elements enriched
in neutral saccharides; the second stage - that in polygalacturonic
acid. The molecular mass is likely to cause phase
conversion of hydrolysis products from gel into solution is about
10 kDa. There is dependence between fraction composition and
duration of the hydrolysis.
and low-etherified pectins in 0.5МHCl at 90°С. The acid hydrolysis
of high-etherified pectin is characterized by decreasing
extent of etherification and production of low-etherified pectin.
In case of low-etherified pectin hydrolysis, the rate rapidly
decreases during the first 1.5 hours, and then remains almost
unchanged. The first stage includes production of elements enriched
in neutral saccharides; the second stage - that in polygalacturonic
acid. The molecular mass is likely to cause phase
conversion of hydrolysis products from gel into solution is about
10 kDa. There is dependence between fraction composition and
duration of the hydrolysis.
66-69 319
Abstract
The experiment conducted on laboratory animals
(mice and rats) allowed to estimate biological activity of Baical
skullcap-based dry extract derived from materials introduced in
Primorsky Krai. This drug proved to regulate the pattern of behavioral
responses modified due to the action of man-induced
xenobiotics, and had anti-oxidative effect in stabilizing hepatocyte
membranes on the ethanol-induced hepatitis model.
(mice and rats) allowed to estimate biological activity of Baical
skullcap-based dry extract derived from materials introduced in
Primorsky Krai. This drug proved to regulate the pattern of behavioral
responses modified due to the action of man-induced
xenobiotics, and had anti-oxidative effect in stabilizing hepatocyte
membranes on the ethanol-induced hepatitis model.
69-71 345
Abstract
The experiment conducted on laboratory animals
(mice) allowed to estimate biological activity of Polygonum Sachalinense
dry extract derived from plants growing in Primorsky
Krai. This drug allows recovering the pattern of behavioral response
modified due to man-induced xenobiotics.
(mice) allowed to estimate biological activity of Polygonum Sachalinense
dry extract derived from plants growing in Primorsky
Krai. This drug allows recovering the pattern of behavioral response
modified due to man-induced xenobiotics.
72-74 241
Abstract
The experiments on SHK male-mice showed optimization
of animal's physical capabilities under chronic noise
effects (80 dB within 4 hours during 20 days). Intragastric introduction
of this drug at a dose of 1 ml/kg twice a day has increased
duration of swimming until absolute fatigue (with 7% load on
the tail). The eleuterococus exhibited energy-saving effects under
the noise stress and hindered exhaustion of glycogen and adenosine
triphosphate reserves in liver and skeletal muscles.
of animal's physical capabilities under chronic noise
effects (80 dB within 4 hours during 20 days). Intragastric introduction
of this drug at a dose of 1 ml/kg twice a day has increased
duration of swimming until absolute fatigue (with 7% load on
the tail). The eleuterococus exhibited energy-saving effects under
the noise stress and hindered exhaustion of glycogen and adenosine
triphosphate reserves in liver and skeletal muscles.
75-77 197
Abstract
The kinetics of cerium sorption by pectin low- and
high-esterified is described. Maximum cerium-binding activity
was found in the pH range from 2 to 6. The Langmuir sorption
model was applied to describe the isotherms and constants. The
results obtained through the study suggest that polysaccharides are
favorable sorbents. The largest amount of cerium ions are bound
by pectin with the degree of esterification close to zero. Therefore,
it can be concluded that low esterified pectins are more effective
substances for elimination of cerium ions from aqueous disposals.
high-esterified is described. Maximum cerium-binding activity
was found in the pH range from 2 to 6. The Langmuir sorption
model was applied to describe the isotherms and constants. The
results obtained through the study suggest that polysaccharides are
favorable sorbents. The largest amount of cerium ions are bound
by pectin with the degree of esterification close to zero. Therefore,
it can be concluded that low esterified pectins are more effective
substances for elimination of cerium ions from aqueous disposals.
78-81 307
Abstract
The authors present results of anatomic study into
grass of six wormwood species known to grow in Primorsky Krai:
Russian wormwood (Artemisia gmelinii Web.), Sievers›s Wormwood
(Artemisia sieversiana Willd.), Virgate wormwood(Artemisia
scoparia Waldst. et Kit.), Argy wormwood (Artemisia агgуi Levl.
еt Vaniot.), Manchurian wormwood (Artemisia mandshurica
Kom.) and Rubripe wormwood(Artemisia rubripes Nakai), and
describe in detail anatomic organization of leaves, inflorescence
cover leaves, and tubular flowers of wormwood. The microscopic
analysis data can be used to prove identity of wormwood species
and probability of distinguishing them from other species.
grass of six wormwood species known to grow in Primorsky Krai:
Russian wormwood (Artemisia gmelinii Web.), Sievers›s Wormwood
(Artemisia sieversiana Willd.), Virgate wormwood(Artemisia
scoparia Waldst. et Kit.), Argy wormwood (Artemisia агgуi Levl.
еt Vaniot.), Manchurian wormwood (Artemisia mandshurica
Kom.) and Rubripe wormwood(Artemisia rubripes Nakai), and
describe in detail anatomic organization of leaves, inflorescence
cover leaves, and tubular flowers of wormwood. The microscopic
analysis data can be used to prove identity of wormwood species
and probability of distinguishing them from other species.
82-84 182
Abstract
Using models of passaged Ehrlich adenocarcinoma
in mice, the authors have studied effects of chitosans with different
molecular mass (190 to 300 and 50 to 190 kDa). The chitosans
were introduced orally at a dose of 50 and 100 mg/kg. Both
specimens did not have effect on the Ehrlich adenocarcinoma
growth but had reliable anti-tumor effect of cyclophosphane.
in mice, the authors have studied effects of chitosans with different
molecular mass (190 to 300 and 50 to 190 kDa). The chitosans
were introduced orally at a dose of 50 and 100 mg/kg. Both
specimens did not have effect on the Ehrlich adenocarcinoma
growth but had reliable anti-tumor effect of cyclophosphane.
84-86 321
Abstract
This paper presents an assessment of the innovative
potential of state-run pharmacies. The techniques used in it are
adequate to identify innovative potential levels and a pharmacy's
innovative development strategy, based on its performance
analysis. The suggested assessment system may serve as a tool for
identification of pharmacies with good potential for innovative
development to be supported by investment capital.
potential of state-run pharmacies. The techniques used in it are
adequate to identify innovative potential levels and a pharmacy's
innovative development strategy, based on its performance
analysis. The suggested assessment system may serve as a tool for
identification of pharmacies with good potential for innovative
development to be supported by investment capital.
87-90 199
Abstract
298 visitors were questionnaired in the pharmacies
of the Belgorod Oblast. The responses allowed identifying four
blocks of problems. These were buyers' problems with assortment
of drugs and prices; buyers' problems with a pharmacy as
a medical institution; problems with interior design; and ethical
and deontological problems.
The authors have conducted TRIZ-analysis of every block and
developed measures (diversions) aimed to eliminate them.
of the Belgorod Oblast. The responses allowed identifying four
blocks of problems. These were buyers' problems with assortment
of drugs and prices; buyers' problems with a pharmacy as
a medical institution; problems with interior design; and ethical
and deontological problems.
The authors have conducted TRIZ-analysis of every block and
developed measures (diversions) aimed to eliminate them.
91-93 315
Abstract
Via black-box modeling, the authors have estimated
innovation activities of 21 pharmacies. According to the directororiented
questionnaires, the innovation activity ranged between
29 and 91%. Most of pharmacies (61.9%) exhibited the innovation
activities in the range of 40 to 75%. The authors recommend
this method for measuring competitive strength of both pharmacies
and their suppliers and rivals.
innovation activities of 21 pharmacies. According to the directororiented
questionnaires, the innovation activity ranged between
29 and 91%. Most of pharmacies (61.9%) exhibited the innovation
activities in the range of 40 to 75%. The authors recommend
this method for measuring competitive strength of both pharmacies
and their suppliers and rivals.
94-96 218
Abstract
The authors present a modified pharma-economic
index of cost-efficiency analysis that makes it possible to allow
for loss of patients when treating chronic diseases - inflation
coefficient. It can be deemed as more reliable tool for estimating
costs needed to treat recurrent diseases than that used today
(Cost-Effectiveness Analysis).
index of cost-efficiency analysis that makes it possible to allow
for loss of patients when treating chronic diseases - inflation
coefficient. It can be deemed as more reliable tool for estimating
costs needed to treat recurrent diseases than that used today
(Cost-Effectiveness Analysis).
97-99 227
Abstract
The paper provides results of questioning of 400
pharmaceutists and pharmaceutical chemists aimed to study
their preferences likely to have effect on consumption of immune-
modulating drugs. The top rating positions mostly included
nonprescription drugs. In choosing drugs, the respondents
frequently have rested on own experience and literature. The
pharmaceutical personnel preferred advising drugs of high clinical
efficiency and possibility of applying in both acute period and
during remission.
pharmaceutists and pharmaceutical chemists aimed to study
their preferences likely to have effect on consumption of immune-
modulating drugs. The top rating positions mostly included
nonprescription drugs. In choosing drugs, the respondents
frequently have rested on own experience and literature. The
pharmaceutical personnel preferred advising drugs of high clinical
efficiency and possibility of applying in both acute period and
during remission.
100-101 262
Abstract
The questioning of 231 specialists conducted in 2005
and 2009 allowed to analyze problems in 'doctor-pharmaceutical
personnel-patient' chain, and show a need to establish close
liaison in efforts to enhance quality of rendering medical and
pharmaceutical aid and improve quality of patients' life.
and 2009 allowed to analyze problems in 'doctor-pharmaceutical
personnel-patient' chain, and show a need to establish close
liaison in efforts to enhance quality of rendering medical and
pharmaceutical aid and improve quality of patients' life.
102-104 263
Abstract
The target number one today is to manufacture
drug products that do not require complex implementation
and therefore are deemed as low-cost. The authors have created
a method of deriving juice and syrup from Sargenta arrow-
wood fruits. This form of syrup is chosen due to its convenience
in applying in pediatric practice. Unlike the alcoholbased
drugs, the plant-derived syrups contain more biologically
active substances. The chemical analysis of both juice
and syrup allows to standardize the raw material and derived
product as finished drug.
drug products that do not require complex implementation
and therefore are deemed as low-cost. The authors have created
a method of deriving juice and syrup from Sargenta arrow-
wood fruits. This form of syrup is chosen due to its convenience
in applying in pediatric practice. Unlike the alcoholbased
drugs, the plant-derived syrups contain more biologically
active substances. The chemical analysis of both juice
and syrup allows to standardize the raw material and derived
product as finished drug.
104-105 214
Abstract
Using data from the experience acquired in the Municipal
Clinical Hospital No.2 in Vladivostok, the authors have
conducted comparative analysis of catgut suture and vycril suture
applied to provide surgical treatment of patients for urologic
pathology. As a result, vycril suture allows decreasing consumption
of this material during the surgery, reducing in-treatment
period, improving patient's quality of life, and reducing costs for
supplementary drug therapy.
Clinical Hospital No.2 in Vladivostok, the authors have
conducted comparative analysis of catgut suture and vycril suture
applied to provide surgical treatment of patients for urologic
pathology. As a result, vycril suture allows decreasing consumption
of this material during the surgery, reducing in-treatment
period, improving patient's quality of life, and reducing costs for
supplementary drug therapy.
106-107 286
Abstract
The authors analyze effect of normobaric hypoxytherapy
on the gestation course and act of delivery while observing
78 women with arterial hypotonia. The two-week course of
the hypoxytherapy against the traditional treatment administered
on the 24-26 gestation weeks considerably decreased the
risk of gestational toxicosis and frequency of premature labour.
The paper discusses the mechanism of how the procedure acts
upon lipid peroxygenation, anti-oxidative system activity, lipid
metabolism, and uterine, fetal and placental circulation.
on the gestation course and act of delivery while observing
78 women with arterial hypotonia. The two-week course of
the hypoxytherapy against the traditional treatment administered
on the 24-26 gestation weeks considerably decreased the
risk of gestational toxicosis and frequency of premature labour.
The paper discusses the mechanism of how the procedure acts
upon lipid peroxygenation, anti-oxidative system activity, lipid
metabolism, and uterine, fetal and placental circulation.
ISSN 1609-1175 (Print)
